MGluR5 Mediates the Interaction between Late-LTP, Network Activity, and Learning
Figure 6
Hippocampal network activity is altered in animals treated with an mGluR5 antagonist.
A, B. Relative theta (5–10 Hz, A) and gamma (30–100 Hz, B) power in the dentate gyrus prolonged treatment with vehicle (open circles), MPEP alone (filled squares) or MPEP with Ro67-4853 (filled triangles). Note that potentiation of mGluR1 with Ro67-4853 partially prevented the suppression of gamma oscillations, which was caused by prolonged MPEP treatment. The values represent averaged data for five 4-s epochs selected after test-pulses at each time-point and normalised to pre-injection values (mean±S.E.M.). Curve-fits are plotted based on distance weighted least squares for time-points after HFT.