Anthelmintic Potential of Thymoquinone and Curcumin on Fasciola gigantica
Fig 6
The reduced glutathione (GSH) levels in Fasciola gigantica worms treated with curcumin (A) and thymoquinone (B). The treatment of liver flukes with both curcumin and thymoquinone caused a significant decrease in the level of GSH that may be disrupting the redox-balance within the parasite. NC: RPMI control, D: DMSO control, Curcumin at 20 μM (C20), 40 μM (C40) and 60 μM (C60); and thymoquinone at 20 μM (T20), 40 μM (T40) and 60 μM (T60) concentrations. All the experiments were carried out in triplicate ±S.E.M. *: p<0.05, ***: p<0.001