Disease progression in mice exposed to low-doses of aerosolized clinical isolates of Burkholderia pseudomallei
Fig 9
Changes in cytokine/chemokine levels in spleen homogenates from BALB/c and C57BL/6 mice after aerosol exposure to B. pseudomallei.
Spleen homogenates were examined for cytokine/chemokine expression at different times after exposure of BALB/c or C57BL/6 mice to HBPUB10134a, or MSHR5855, or 1106a. For each time point after exposure N = 5, and geometric means were determined. Fold changes in cytokines/chemokines in spleen homogenates were determined by dividing the amount in geometric means (pg/ml) determined after exposure at a specific time by the amount found in lung homogenates from naïve, normal BALB/c or C57BL/6 mice (pg/ml). For cytokines/chemokines in spleens from naïve BALB/c mice, N = 4 and for C57BL/6 mice, N = 5. The numbers on the left of each panel shows the days after exposure. The bar on the right of each heat map shows the fold-change in expression of each cytokine/chemokine after time of exposure.