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Predictive Factors of Weight Loss 1 Year after Laparoscopic Gastric Bypass in Obese Patients

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Abstract

Background

Substantial weight loss is achieved in majority of severely obese subjects undergoing laparoscopic gastric bypass (LGBP) but some fail to obtain expected results. Our aim was to identify preoperative factors that could influence weight loss (WL) 1 year after LGBP.

Methods

We studied the predictive value of clinical, biological, and dietary preoperative factors on weight loss in obese patients referred for LGBP. WL was assessed according to mean absolute weight loss (AWL) and mean percent excess weight loss (%EWL) 1 year after LGBP.

Results

One hundred twenty-three subjects were included (112 women, age 42 ± 10 years; weight 127 ± 23 kg; BMI 47 ± 8 kg/m2). Mean AWL was 39.4 ± 10.5 kg at 1 year, corresponding to a mean %EWL of 70.5 ± 21.2%. AWL was positively correlated with initial weight, BMI, and energy intake and negatively with age, female sex, and treatment for hypertension and diabetes. %EWL was negatively correlated with initial weight, BMI, and positively correlated with triglycerides and ferritinemia. In multivariate analysis, %EWL was negatively correlated only with initial BMI (p < 0.001). AWL was positively correlated with initial BMI and male sex (both p < 0.001), and negatively correlated with protein intake (p = 0.039) and treatment for diabetes (p = 0.021), but not with biomarkers of diabetes and insulin resistance.

Conclusion

Initial BMI appears to be a strong determinant of individual WL, but predictive factors differ when WL was expressed as %EWL or AWL. The treatment of diabetes rather than diabetes itself appears to affect WL.

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Acknowledgments

We thank Karin Puchaux, Pauline Chenebault, Marie Christine Breuil, and Laurence Babouin for their help in recording nutritional survey.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Service des Explorations Fonctionnelles, Centre de référence de l’obésité AP-HP, Hôpital Louis Mourier (AP-HP), Université Paris 7 Denis Diderot, Colombes, France

    Muriel Coupaye, Christine Clérici & Séverine Ledoux

  2. Service de Gastroentérologie, Centre de référence de l’obésité AP-HP, Hôpital Louis Mourier (AP-HP), Université Paris 7 Denis Diderot, Colombes, France

    Jean Marc Sabaté & Pauline Jouet

  3. Service de Chirurgie Digestive, Centre de référence de l’obésité AP-HP, Hôpital Louis Mourier (AP-HP), Université Paris 7 Denis Diderot, Colombes, France

    Benjamin Castel & Simon Msika

  4. Service des Explorations Fonctionnelles, hôpital Louis Mourier (AP-HP), 178 rue des Renouillers, 92701, Colombes Cedex, France

    Muriel Coupaye

Authors
  1. Muriel Coupaye
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  2. Jean Marc Sabaté
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  7. Séverine Ledoux
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Correspondence to Muriel Coupaye.

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Supplemental Table 1

Multivariate regression model in women (DOC 20 kb)

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Coupaye, M., Sabaté, J.M., Castel, B. et al. Predictive Factors of Weight Loss 1 Year after Laparoscopic Gastric Bypass in Obese Patients. OBES SURG 20, 1671–1677 (2010). https://doi.org/10.1007/s11695-010-0159-2

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  • DOI: https://doi.org/10.1007/s11695-010-0159-2

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