The First Department of Internal Medicine, Kyorin University, School of Medicine
The First Department of Internal Medicine, Kyorin University, School of Medicine
The First Department of Internal Medicine, Kyorin University, School of Medicine
The First Department of Internal Medicine, Asahikawa Medical University
The First Department of Internal Medicine, Asahikawa Medical University
Iwamizawa Rosai Hospital
The First Department of Internal Medicine, Hokkaido University, School of Medicine
The First Department of Internal Medicine, Hokkaido University, School of Medicine
The First Department of Internal Medicine, Hokkaido University, School of Medicine
The First Department of Internal Medicine, Hokkaido University, School of Medicine
The First Department of Internal Medicine, Hokkaido University, School of Medicine
The Second Department of Internal Medicine, Hokkaido University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Hokkaido University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Hokkaido University, School of Medicine and Related Hospitals
Department of Respiratory Disease, Sapporo Hospital of Japanese National Railway
Department of Respiratory Disease, Sapporo Hospital of Japanese National Railway
Department of Respiratory Disease, Sapporo Hospital of Japanese National Railway
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, School of Medicine, Iwate Medical University
The Third Department of Internal Medicine, School of Medicine, Iwate Medical University
The Third Department of Internal Medicine, School of Medicine, Iwate Medical University
The First Department of Internal Medicine, Tohoku University, School of Medicine
The First Department of Internal Medicine, Tohoku University, School of Medicine
The First Department of Internal Medicine, Tohoku University, School of Medicine
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University
Respiratory Division, Iwaki Kyoritsu General Hospital
Respiratory Division, Iwaki Kyoritsu General Hospital
Department of Internal Medicine, National Sanatorium Seiranso Hospital
Department of Internal Medicine, National Sanatorium Seiranso Hospital
Department of Internal Medicine, Kasumigaura National Hospital
Department of Internal Medicine, Kasumigaura National Hospital
The Second Department of Internal Medicine, Niigata University, School of Medicine
Department of Internal Medicine, Shinrakuen Hospital
Department of Internal Medicine, Shinrakuen Hospital
Department of Internal Medicine, Shinrakuen Hospital
Department of Internal Medicine, Shinrakuen Hospital
Department of Internal Medicine, Shinrakuen Hospital
Department of Internal Medicine, Suibarago Hospital
Department of Internal Medicine, Suibarago Hospital
The Second Department of Internal Medicine, The Jikei University School of Medicine
The Second Department of Internal Medicine, The Jikei University School of Medicine
The Second Department of Internal Medicine, The Jikei University School of Medicine
Department of Internal Medicine, Tokyo Kyosai Hospital
Department of Internal Medicine, Tokyo Kyosai Hospital
Department of Internal Medicine, Tokyo Kyosai Hospital
Department of Internal Medicine, Tokyo Kyosai Hospital
Department of Internal Medicine, Tokyo Koseinenkin Hospital
Department of Internal Medicine, Tokyo Koseinenkin Hospital
Department of Internal Medicine, Tokyo Koseinenkin Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Internal Medicine, Juntendo University, School of Medicine
Department of Internal Medicine, Juntendo University, School of Medicine
Department of Internal Medicine, Tokyo Metropolitan Geriatric Hospital
Department of Internal Medicine, Tokyo Metropolitan Geriatric Hospital
Department of Internal Medicine, Tokyo Metropolitan Geriatric Hospital
Department of Internal Medicine, Tokyo Denryoku Hospital
Department of Internal Medicine, Tokyo Denryoku Hospital
The First Department of Internal Medicine, Tokyo Women's Medical College
The First Department of Internal Medicine, Tokyo Women's Medical College
Pulmonary Division, National Medical Center Hospital
Pulmonary Division, National Medical Center Hospital
Pulmonary Division, National Medical Center Hospital
Pulmonary Division, National Medical Center Hospital
Department of Internal Medicine, Kawasaki Municipal Hospital
Department of Internal Medicine, Kawasaki Municipal Hospital
Department of Internal Medicine, Kawasaki Municipal Hospital
Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
Department of Internal Medicine, Yokohama Teishin Hospital
Department of Internal Medicine, Kanagawa Prefecture Midwives and Nurses Training School Hospital
Department of Internal Medicine, Toyama Prefectural Central Hospital
Department of Internal Medicine, Toyama Prefectural Central Hospital
The First Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospitals
The First Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospitals
The First Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospitals
The First Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospitals
The First Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospitals
The First Department of Internal Medicine, Nagoya City University School of Medicine and Related Hospitals
The First Department of Internal Medicine, Nagoya City University School of Medicine and Related Hospitals
The First Department of Internal Medicine, Nagoya City University School of Medicine and Related Hospitals
The First Department of Internal Medicine, Nagoya City University School of Medicine and Related Hospitals
Department of Internal Medicine, Nagoya Koseiin Geriatric Hospital
[in Japanese] Department of Internal Medicine, Fujita Gakuen University, School of Medicine
[in Japanese] Department of Internal Medicine, Fujita Gakuen University, School of Medicine
The First Department of Internal Medicine, Chest Disease Research Institute Kyoto University and Related Hospitals
The First Department of Internal Medicine, Chest Disease Research Institute Kyoto University and Related Hospitals
The First Department of Internal Medicine, Chest Disease Research Institute Kyoto University and Related Hospitals
The First Department of Internal Medicine, Chest Disease Research Institute Kyoto University and Related Hospitals
The First Department of Internal Medicine, Chest Disease Research Institute Kyoto University and Related Hospitals
The First Department of Internal Medicine, Chest Disease Research Institute Kyoto University and Related Hospitals
The First Department of Internal Medicine, Chest Disease Research Institute Kyoto University and Related Hospitals
The First Department of Internal Medicine, Chest Disease Research Institute Kyoto University and Related Hospitals
The First Department of Internal Medicine, Chest Disease Research Institute Kyoto University and Related Hospitals
The First Department of Internal Medicine, Chest Disease Research Institute Kyoto University and Related Hospitals
The First Department of Internal Medicine, Chest Disease Research Institute Kyoto University and Related Hospitals
The First Department of Internal Medicine, Chest Disease Research Institute Kyoto University and Related Hospitals
The First Department of Internal Medicine, Chest Disease Research Institute Kyoto University and Related Hospitals
The First Department of Internal Medicine, Chest Disease Research Institute Kyoto University and Related Hospitals
The First Department of Internal Medicine, Chest Disease Research Institute Kyoto University and Related Hospitals
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Izumi Municipal Hospital
The First Department of Internal Medicine, Kansai Medical University
The First Department of Internal Medicine, Kansai Medical University
The First Department of Internal Medicine, Kansai Medical University
The First Department of Internal Medicine, Kansai Medical University
The First Department of Internal Medicine, Kansai Medical University
Department of Internal Medicine, Rakusai New Town Hospital, Kansai Medical University
Department of Internal Medicine, Rakusai New Town Hospital, Kansai Medical University
Division of Respiratory Diseases of Internal Medicine, Kawasaki Medical School
Division of Respiratory Diseases of Internal Medicine, Kawasaki Medical School
Division of Respiratory Diseases of Internal Medicine, Kawasaki Medical School
Division of Respiratory Diseases of Internal Medicine, Kawasaki Medical School
Division of Respiratory Diseases of Internal Medicine, Kawasaki Medical School
Department of Internal Medicine, Kure National Hospital
Department of Internal Medicine, Kure National Hospital
Department of Internal Medicine, Kure National Hospital
Department of Internal Medicine, Kure National Hospital
The Second Department of Internal Medicine, Hiroshima University School of Medicine
The Second Department of Internal Medicine, Hiroshima University School of Medicine
The Second Department of Internal Medicine, Hiroshima University School of Medicine
The Second Department of Internal Medicine, Hiroshima University School of Medicine
The Third Department of Internal Medicine, Tokushima University, School of Medicine
The Third Department of Internal Medicine, Tokushima University, School of Medicine
The Third Department of Internal Medicine, Tokushima University, School of Medicine
School of Health Sciences, Kyushu University The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
School of Health Sciences, Kyushu University The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
School of Health Sciences, Kyushu University The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
Department of Internal Medicine, The National Minami Fukuoka Chest Hospital
Department of Internal Medicine, The National Minami Fukuoka Chest Hospital
Department of Internal Medicine, The National Minami Fukuoka Chest Hospital
The Second Department of Internal Medicine, Medical College of Oita
The Second Department of Internal Medicine, Medical College of Oita
The Second Department of Internal Medicine, Medical College of Oita
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University School of Medicine and Related Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Related Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Related Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Related Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Related Hospitals
The First Department of Internal Medicine, Kumamoto University, School of Medicine
The First Department of Internal Medicine, Kumamoto University, School of Medicine
The First Department of Internal Medicine, Kumamoto University, School of Medicine
Department of Internal Medicine, Kumamoto Rosai Hospital
Department of Internal Medicine, Kumamoto Rosai Hospital
Department of Internal Medicine, Kumamoto Rosai Hospital
Department of Internal Medicine, Kumamoto Municipal Hospital
Department of Internal Medicine, Kumamoto Municipal Hospital
Department of Internal Medicine, Kumamoto Municipal Hospital
The First Department of Internal Medicine, University of the Ryukyus, School of Medicine
The First Department of Internal Medicine, University of the Ryukyus, School of Medicine
The First Department of Internal Medicine, University of the Ryukyus, School of Medicine
1984 Volume 58 Issue 6 Pages 525-555
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The clinical effectiveness and side effects of DL-8280 in the treatment of lower respiratory tract infections including pneumonias were compared with those of amoxicillin (AMPC) by a double-dummy fashion.
The following diseases were included in this study; infectious exacerbation of chronic bronchitis and diffuse panbronchiolitis, chronic respiratory tract diseases with infections (bronchiectasis, bronchial asthma, pulmonary emphysema, lung fibrosis, inactive pulmonary tuberculosis) and various kinds of bacterial pneumonias.
Two hundred mg dose of DL-8280 was orally administered 3 times per day and 250 mg dose of AMPC was orally administered 4 times per day. Out of all 279 patients, DL-8280 was used in 139patients and AMPC was in 140 patients. Clinical effectiveness and side effects were observed and the obtained results were as follows.
1) One hundred and twenty-two patients of DL-8280 group and 115 patients of AMPC group were evaluated on clinical effectiveness. In DL-8280 group, 6 patients were judgedas “Excellent”, 89 as “Good”, 16 as “Fair”, 10 as “Poor” and its effectiveness rate was 78.5%. On the other hand, in AMPC group, 5 patients were judged as “Excellent”, 73 as “Good”, 14 as “Fair”, 22 as “Poor” and the effectiveness rate was 68.4%. However, one unevaluable patient was seen in each group. The clinical effectiveness of DL-8280 was superior to that of AMPC, especially, the effectiveness rate of DL-8280 group was significantly higher in chronic bronchitis.
2) Bacteriologically, the eradication rate of 88.6% was observed out of 79 clinical isolates in DL-8280 group and it was 61.1% in 72 clinical isolates in AMPC group. These results revealed the significant superiority of DL-8280 to AMPC. Particularly, the bacteriological response of DL-8280 against H. influenzae was significantly superior to that of AMPC.
3) Side effects were noted in 6.1% of 132 patients with DL-8280 and 7.7% of 130 patients with AMPC, and abnormal changes in laboratory findings were noted in 11.1% in DL-8280 group and 14.2% in AMPC group after administration. There was no significant difference between two groups. Neither progressive side effect nor remarkable change in laboratory findings was noted.
4) From these results, it was concluded that DL-8280 was more useful agent than AMPC in the treatment for lower respiratory tract infections, particularly chronic complicated cases.