Intro -- Preface -- Acknowledgements -- Contents -- Introduction -- 1 The Italian Flagship Project: Factories of the Future -- 1.1 The Importance of Manufacturing Industry -- 1.2 Italian Manufacturing Industry -- 1.3 International Research Initiatives on Manufacturing -- 1.4 Italian Research Initiatives on Manufacturing -- 1.4.1 Flagship Projects -- 1.4.2 Technological Clusters -- 1.4.3 National Plan Enterprise 4.0 -- 1.5 Flagship Project Factories of the Future -- 1.5.1 Strategic Macro-objectives -- 1.5.2 Enabling Technologies -- 1.5.3 Calls for Proposals and Research Projects -- 1.5.4 Results of the Flagship Project -- References -- Evolutionary and Reconfigurable Factory -- 2 Model Predictive Control Tools for Evolutionary Plants -- 2.1 Scientific and Industrial Motivations -- 2.2 State of the Art -- 2.3 Problem Statement and Proposed Approach -- 2.4 MPC-Based Control Platform -- 2.4.1 Main_program -- 2.4.2 Task_Manager -- 2.4.3 Line_Supervisor / Plant_j_Line_Supervisor -- 2.4.4 Machine / Machine_j -- 2.4.5 Controller / Controller_j -- 2.4.6 Interface_vs_ext / Interface_vs_Txt_file/TCPIP -- 2.5 Testing and Validation of Results -- 2.5.1 Industrial Case -- 2.5.2 De-manufacturing Pilot Plant Control Platform Implementation -- 2.5.3 Experiments -- 2.6 Conclusions and Future Research -- References -- 3 Exploiting Modular Pallet Flexibility for Product and Process Co-evolution Through Zero-Point Clamping Systems -- 3.1 Scientific and Industrial Motivations -- 3.2 State of the Art -- 3.3 Problem Formalization -- 3.4 Pallet Design and Management Approach -- 3.4.1 Factory Data Model -- 3.4.2 Pallet Configuration -- 3.4.3 Design and Setup of the Pallet Scanner -- 3.4.4 Loading and Optimization -- 3.4.5 Pallet Inspection -- 3.4.6 Machining Process Simulation -- 3.5 Prototype and Testing -- 3.5.1 Pro2ReFix Prototype -- 3.5.2 Experiments.