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Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents [Elektronische Ressource] / M. Michaelis, F. Rothweiler, B. Agha, S. Barth, Y. Voges, N. Löschmann, A. von Deimling, R. Breitling, H. Wilhelm Doerr, F. Rödel, D. Speidel and J. Cinatl Jr

Michaelis, Martin,i1972- ; Rothweiler, Florian,i1978- ; Agha, Bishr,i1986- ; Barth, Susanne,i1974- ; Voges, Yvonne ; Löschmann, Nadine ; Deimling, Andreas von,i1959- ; Breitling, Rainer,i1971- ; Doerr, Hans-Wilhelm ; Rödel, Franz,i1963- ; Speidel, Daniel,i1973- ; Cinatl, Jindrich

Adaptation of wild-type p53 expressing UKF-NB-3 cancer cells to the murine double minute 2 inhibitor nutlin-3 causes de novo p53 mutations at high frequency (13/20) and multi-drug resistance. Here, we show that the same cells respond very differently when adapted to RITA, a drug that, like nutlin-3, also disrupts the p53/Mdm2 interaction. All of the 11 UKF-NB-3 sub-lines adapted to RITA that we established retained functional wild-type p53 although RITA induced a substantial p53 response. Moreover, all RITA-adapted cell lines remained sensitive to nutlin-3, whereas only five out of 10 nutlin-3-adapted cell lines retained their sensitivity to RITA. ...

Cell death & disease. - London [u.a.] : Nature Publishing Group, 2010-. - Online-Ressource. - ISSN 2041-4889. - Band 3, Heft 294 (2012)

 

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