Crossroads Between Innate and Adaptive Immunity IV; Preface; Acknowledgements; Contents; Contributors; 1: Vita-PAMPs: Signatures of Microbial Viability; 1.1 Introduction; 1.2 Live Versus Dead Pathogens: Role of Virulence Factors; 1.3 Microbial Viability Detection: Growth and Metabolism; 1.4 Detection of Microbial Viability Independently of Microbial Growth; 1.5 Features of Bacterial mRNAs; 1.6 Bacterial mRNA and Innate Immunity; 1.7 Vita-PAMPs and Adaptive Immunity; 1.8 PRRs That Orchestrate the Response to Bacterial Viability; 1.9 Conclusions; References 2: Innate Lymphoid Cells in Immunity and Disease2.1 Introduction; 2.2 Phenotype of ILCs; 2.2.1 NK Cell Phenotype; 2.2.2 Ror g t-Dependent ILC Phenotype; 2.2.3 Type 2 ILC Phenotype; 2.3 Development of ILCs; 2.3.1 Inhibitor of DNA Binding 2 (Id2): An Early Common "Switch" for ILCs; 2.3.2 NK Cells Development; 2.3.3 Ror g t-Dependent ILCs Development; 2.3.4 Type 2 ILCs Development; 2.4 ILC Roles in the Host Organism; 2.4.1 NK Cells: Cytolytic Activity and Cytokine Production; 2.4.2 LTi Cells and Organogenesis of Lymphoid Structures 2.4.3 Ror g t-Dependent ILCs: IL-17 and IL-22 Producers for Intestinal Homeostasis2.4.4 Type 2 ILCs: Protective Response Against Helminths; 2.4.5 Wound Healing; 2.4.6 Dysregulation of ILCs: Autoimmunity, Allergy, and Fibrosis; 2.5 Conclusion; References; 3: Tuning Cross-Presentation of Apoptotic T Cells in Immunopathology; 3.1 Introduction; 3.2 CD40 Ligand Expression on Apoptotic T Cells Abrogates Tolerance; 3.3 Apoptotic T Cells Are Source of Immunogenic Self-Antigens; 3.4 Relevance of Cross-Presentation of Apoptotic Epitopes in Clinical Setting; 3.5 Conclusion; References 4: Regulation of Type 2 Immunity by Basophils4.1 Basophil Development and Homeostasis; 4.2 The Role of Basophils for Differentiation of Th2 Cells; 4.3 Basophils as Mediators of Allergic Responses; 4.4 Protective Immunity Against Ticks and Helminths; 4.5 Conclusion; References; 5: Crosstalk Between Adaptive and Innate Immune Cells Leads to High Quality Immune Protection at the Mucosal Borders; 5.1 Introduction; 5.2 Effector and Central Memory T Cells Form Distinct Subsets; 5.3 An Innate-Adaptive Crosstalk Drives the Selective Accumulation of Mucosal T EM 5.3.1 Activation-Induced CD8 a a Rescues CD8 ab Primary Effector T Cells from AICD5.3.2 Activation-Induced CD8 a a Rescues CD8 a b Primary Effector T Cells from TICD; 5.3.3 Activation-Induced CD8 a a Rescues CD8 a b Secondary Effector T Cells from TICD; 5.4 Conclusion; 5.5 Future Prospective; References; 6: The Interaction Between Filarial Parasites and Human Monocyte/Macrophage Populations; 6.1 Background; 6.1.1 Lymphatic Filariasis; 6.1.2 Macrophages and Their Role in Inflammation; 6.2 Induction of AAM F s in Filarial Infections; 6.2.1 Animal Models; 6.2.2 Humans 6.3 Implications in Clinical Settings Is Transcription the Dominant Force during Dynamic Changes in Gene Expression? -- MicroRNAs: Key Components of Immune Regulation -- KIR/HLA: Genetic Clues for a Role of NK cells in the Control of HIV -- Natural Killer cell Licensing during Viral Infection -- Bridging Innate NK cell Functions with Adaptive Immunity -- Control of Innate Immunity by Memory CD4 T cells -- Strategies and Implications for Prime-Boost Vaccinations to Generate Memory CD8 T Cells -- Blimp1: Driving Terminal Differentiation to a T -- A new Role for Myeloid HO-1 in the Innate to Adaptive Crosstalk and Immune Homeostasis -- Impact of Differential Glycosylation on IgG Activity -- Murine Model of Chronic Respiratory Inflammation -- Incorporation of Innate Immune Effector Mechanisms in the Formulation of a Vaccine Against HIV-1 -- Influenza Vaccines: What do we Want and How can we Get it?.. |