1819027236

Investigation of transformation products of selected veterinary drugs generated by electrochemistry, microsomal assays, hydrolysis & photolysis / Lisa Knoche

Schwerdtle, Tanja *1975-* [AkademischeR BetreuerIn] ; Koch, Matthias [AkademischeR BetreuerIn] ; Karst, Uwe *1965-* [AkademischeR BetreuerIn]

Englisch

Potsdam, 2022

XI, 163, iii Seiten : Illustrationen, Diagramme

Kumulative Dissertation

Übersetzung des Haupttitels: Untersuchung von Transformationsprodukten ausgewählter Tierarzneimittel generiert durch Elektrochemie, Mikrosomal Assay, Hydrolyse und Photolyse

Dissertation, Universität Potsdam, 2022

*Tierarzneimittel / Reaktionsprodukt / Monensin / Salinomycin / Lasalocid / Lactone / Massenspektrometrie / Tandem-Massenspektrometrie / LC-MS / Simulation / Elektrochemischer Reaktor / Leber / Mikrosom

The knowledge of transformation pathways and transformation products of veterinary drugs is important for health, food and environmental matters. Residues, consisting of original veterinary drug and transformation products, are found in food products of animal origin as well as the environment (e.g., soil or surface water). Several transformation processes can alter the original veterinary drug, ranging from biotransformation in living organism to environmental degradation processes like photolysis, hydrolysis, or microbial processes. In this thesis, four veterinary drugs were investigated, three ionophore antibiotics Monensin, Salinomycin and Lasalocid and the macrocyclic lactone Moxidectin. Ionophore antibiotics are mainly used to cure and prevent coccidiosis in poultry especially prophylactic in broiler farming. Moxidectin is an antiparasitic drug that is used for the treatment of internal and external parasites in food-producing and companion animals. The main objective of this work is to employ different laboratory approaches to generate and identify transformation products. [...]

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