1823047483

Biological evaluation and sulfation of polymer networks from glycerol glycidyl ether / von Shuo Zhou ; Gutachter: Axel T. Neffe, Qian Zhao, Maike Windbergs ; Betreuer: Axel T. Neffe

Neffe, Axel T. *1973-* [AkademischeR BetreuerIn] ; Zhao, Qian [AkademischeR BetreuerIn] ; Windbergs, Maike [AkademischeR BetreuerIn]

Englisch

Potsdam, [2022?]

XVI, 96 Seiten : Illustrationen, Diagramme

kumulative Dissertation

Dissertation, Universität Potsdam, 2022, kumulative Dissertation

*Glycerinderivate / Polyether / Ringöffnungspolymerisation / Funktionalisierung / Adsorption / Biofilm / Antifouling-Wirkstoff / Antimikrobieller Wirkstoff

Cardiovascular diseases are the main cause of death worldwide, and their prevalence is expected to rise in the coming years. Polymer-based artificial replacements have been widely used for the treatment of cardiovascular diseases. Coagulation and thrombus formation on the interfaces between the materials and the human physiological environment are key issues leading to the failure of the medical device in clinical implantation. The surface properties of the materials have a strong influence on the protein adsorption and can direct the blood cell adhesion behavior on the interfaces. Furthermore, implant-associated infections will be induced by bacterial adhesion and subsequent biofilm formation at the implantation site. Thus, it is important to improve the hemocompatibility of an implant by altering the surface properties. One of the effective strategies is surface passivation to achieve protein/cell repelling ability to reduce the risk of thrombosis. This thesis consists of synthesis, functionalization, sterilization, and biological ...

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