274601559

Efficient chemotherapy of rat glioblastoma using Doxorubicin-loaded PLGA nanoparticles with different stabilizers / Stefanie Wohlfart, Alexander S. Khalansky, Svetlana Gelperina, Olga Maksimenko, Christian Bernreuther, Markus Glatzel, Jörg Kreuter

Wohlfart, Stefanie,i1983- ; Khalansky, Alexander S. ; Gelperina, S. E. ; Maksimenko, Olga ; Bernreuther, Christian,i1972- ; Glatzel, Markus,i1969- ; Kreuter, Jörg

Background: Chemotherapy of glioblastoma is largely ineffective as the blood-brain barrier (BBB) prevents entry of most anticancer agents into the brain. For an efficient treatment of glioblastomas it is necessary to deliver anti-cancer drugs across the intact BBB. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles coated with poloxamer 188 hold great promise as drug carriers for brain delivery after their intravenous injection. In the present study the anti-tumour efficacy of the surfactant-coated doxorubicin-loaded PLGA nanoparticles against rat glioblastoma 101/8 was investigated using histological and immunohistochemical methods.

PLOS ONE. - San Francisco, California, US : PLOS, 2006-. - Online-Ressource. - ISSN 1932-6203. - Band 6, Heft 5 (06. Mai 2011), Artikel-ID: e19121

 

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