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Effects of flavonoid-induced oxidative stress on anti-H5N1 influenza A virus activity exerted by baicalein and biochanin A [Elektronische Ressource] / Martin Michaelis, Patchima Sithisarn and Jindrich Cinatl Jr.

Michaelis, Martin,i1972- ; Sithisarn, Patchima,i1978- ; Cinatl, Jindrich Jr.

Background: Different flavonoids are known to interfere with influenza A virus replication. Recently, we showed that the structurally similar flavonoids baicalein and biochanin A inhibit highly pathogenic avian H5N1 influenza A virus replication by different mechanisms in A549 lung cells. Here, we investigated the effects of both compounds on H5N1-induced reactive oxygen species (ROS) formation and the role of ROS formation during H5N1 replication. ...

Biomed Central (London). BMC Research Notes. - London, 2008-. - Online-Ressource. - ISSN 1756-0500. - Band 7, Heft 384 (2014)

 

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