369163958

Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101) / Jens Mani, Stefan Vallo, Stefanie Rakel, Patrick Antonietti, Florian Gessler, Roman Blaheta, Georg Bartsch, Martin Michaelis, Jindrich Cinatl, Axel Haferkamp and Donat Kögel

Mani, Jens,i1978- [Verfasser] ; Vallo, Stefan,i1980- [Verfasser] ; Rakel, Stefanie [Verfasser] ; Antonietti, Patrick [Verfasser] ; Geßler, Florian,i1984- [Verfasser] ; Blaheta, Roman [Verfasser] ; Bartsch, Georg,i1963- [Verfasser] ; Michaelis, Martin,i1972- [Verfasser] ; Cinatl, Jindrich [Verfasser] ; Haferkamp, Axel,i1968- [Verfasser] ; Kögel, Donat [Verfasser]

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Background: Acquired resistance to standard chemotherapy causes treatment failure in patients with metastatic bladder cancer. Overexpression of pro-survival Bcl-2 family proteins has been associated with a poor chemotherapeutic response, suggesting that Bcl-2-targeted therapy may be a feasible strategy in patients with these tumors. The small-molecule pan-Bcl-2 inhibitor (−)-gossypol (AT-101) is known to induce apoptotic cell death, but can also induce autophagy through release of the pro-autophagic BH3 only protein Beclin-1 from Bcl-2. ...

BMC cancer. - London : BioMed Central, 2001-. - Online-Ressource. - ISSN 1471-2407. - Band 15, Heft 224 (2015)

 

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