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Preface -- Contents -- Abbreviations -- Contributors -- 1: Understanding the Pathophysiology of Penile Cancer and Its Preneoplastic Lesions -- Epidemiology of Penile Cancer -- Risk Factors for Penile Carcinoma -- Pathophysiology -- Human Papillomavirus -- HPV-Mediated Pathway -- HPV-Independent Pathway -- Penile Cancer Precursor Lesions -- Condyloma Acuminatum -- Giant Condyloma Acuminatum (Buschke-Lowenstein Tumor) -- Bowenoid Papulosis -- Lichen Sclerosus (Balanitis Xerotica Obliterans) -- Carcinoma In Situ (Erythroplasia of Queyrat and Bowen's Disease) -- Histologic Subtypes
Conclusions -- References -- 2: Diagnostic Tools in the Evaluation and Management of Penile Cancer -- Introduction -- Novel Image-Based Diagnostic Tools -- Evaluation and Management of the Primary Penile Lesion -- Evaluation and Management of Loco-Regional Metastatic Lymphatic Spread -- Penile Cancer Biomarkers -- p53 -- p16INK4a -- Ki-67 -- Proliferating Cell Nuclear Antigen -- C-Reactive Protein -- Cyclin D1 -- Other Biomarkers -- Conclusions -- References -- 3: Penile-Sparing Surgical Approaches in the Management of Primary Penile Tumours -- Introduction -- Basis for Penile-Preserving Surgery
Topical Therapies -- Suitable for Stage Tis Disease Only -- 5 % 5-Fluorouracil (5-FU) -- Imiquimod -- Laser Therapy -- For Stage Tis, But Has Been Used Up to Stage T2 Lesions -- Penile-Sparing Surgical Techniques -- Circumcision -- For Lesions Confined to the Prepuce -- Total Glans Resurfacing -- For Glanular Tis/Ta and Up to Stage T1a Disease -- Partial Glans Resurfacing -- For Isolated Foci of Tis/Ta Affecting < 50 % of Glans -- Moh's Micrographic Surgery -- For Stage T1a, But Has Been Used Up to Stage T3 -- Wide Local Excision/Partial Glansectomy
For Small, Discrete Lesions on the Glans Up to Stage T1a -- Glansectomy and Reconstruction -- For Stage T1b/T2 Tumours Confined to the Glans -- Distal Corporectomy/Partial Penectomy and Reconstruction -- For Stage T2b/Distal T3 Disease -- Conclusions -- References -- 4: Dynamic Sentinel Node Biopsy and FDG-PET/CT for Lymph Node Staging in Penile Cancer -- Introduction -- Risk-Adapted Approach -- Dynamic Sentinel Node Biopsy -- FDG-PET/CT -- Conclusion -- References
5: Surgical Decision-Making, Technical Considerations, and Clinical Pearls in Therapeutic Inguinal Node Dissection for Penile Cancer -- Surgical Decision-Making in Patients with CN +ve Penile Cancer -- Unresectable Inguinal Lymphadenopathy -- Role of Systemic Therapy in High-Volume Lymph Node Metastasis -- Technical Considerations Among Patients Undergoing Lymphadenectomy for Clinically Positive Nodes -- Initial Resection of Clinically Mobile Nodes Less Than 4 cm with No Overlying Skin Fixation -- Perioperative Care -- Patient Position -- Skin Incision -- Surgical Boundaries
Clinically Node Positive Inguinal Field
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