5-HT2A Receptors in the Central Nervous System

1. Front Matter

   Pages i-xii

   PDF

2. Properties and Distribution of the 5-HT2AR

   1. Front Matter

      Pages 1-1

      PDF

   2. Pharmacological Analysis in Favour of a Physiological Role for the Constitutive Activity of 5-HT2A Receptors in Learning

      • Philippe De Deurwaerdère, Guillaume Drutel, Giuseppe Di Giovanni

      Pages 3-29

   3. βArrestins: Ligand-Directed Regulators of 5-HT2A Receptor Trafficking and Signaling Events

      • Cullen L. Schmid, Laura M. Bohn

      Pages 31-55

   4. 5-HT2A Receptor Heterodimerization

      • Sylwia Łukasiewicz, Ewa Błasiak, Marta Dziedzicka-Wasylewska

      Pages 57-66

   5. Brain Distribution

      • Cristiano Bombardi

      Pages 67-84

   6. PET Imaging of the 5-HT2A Receptor System: A Tool to Study the Receptor’s In Vivo Brain Function

      • Matthias M. Herth, Gitte M. Knudsen

      Pages 85-134

3. 5-HT2AR Related Brain Functions

   1. Front Matter

      Pages 135-135

      PDF

   2. Serotonergic Receptor 5-HT2A in the Cardiosympathovagal System

      • M. Kermorgant, A. Pavy-Le Traon, J. M. Senard, D. N. Arvanitis

      Pages 137-145

   3. Crosstalk Between 5-HT2A and mGlu2 Receptors: Implications in Schizophrenia and Its Treatment

      • José L. Moreno, Javier González-Maeso

      Pages 147-189

   4. Schizophrenia

      • Anna Castañé, Albert Adell

      Pages 191-204

   5. Role of Serotonin-2A Receptors in Pathophysiology and Treatment of Depression

      • Lucia Moravčíková, Kristína Csatlósová, Barbora Ďurišová, Katarína Ondáčová, Michaela Pavlovičová, Ľubica Lacinová et al.

      Pages 205-230

   6. Brain Circuits Regulated by the 5-HT2A Receptor: Behavioural Consequences on Anxiety and Fear Memory

      • L. Moulédous, P. Roullet, Bruno P. Guiard

      Pages 231-258

   7. 5-HT2A/2B/2C Receptors, Memory and Therapeutic Targets

      • Alfredo Meneses, Rossana Nieto-Vera, Rosa María Anaya-Jiménez

      Pages 259-271

   8. 5-HT2A Receptors in the Basal Ganglia

      • Cristina Miguelez, Teresa Morera-Herreras, Philippe De Deurwaerdère

      Pages 273-310

   9. The Involvement of 5-HT2A Receptor in the Regulation of Sleep and Wakefulness, and the Potential Therapeutic Use of Selective 5-HT2A Receptor Antagonists and Inverse Agonists for the Treatment of an Insomnia Disorder

      • Jaime M. Monti, Seithikurippu R. Pandi Perumal, D. Warren Spence, Pablo Torterolo

      Pages 311-337

   10. 5-HT2A Receptors and Pain

       • Christine Courteix, Amandine Dupuis, Pierre-Yves Martin, Benoit Sion

       Pages 339-352

   11. 5-HT2A Receptors in Eating Disorders

       • Philip Gorwood, Laurence Lanfumey, Odile Viltart, Nicolas Ramoz

       Pages 353-373

   12. Role of Serotonin2A (5-HT2A) Receptors in Epilepsy

       • Vincenzo Crunelli, Marcello Venzi, Philippe De Deurwaerdère, Giuseppe Di Giovanni

       Pages 375-394

   13. 5-HT2A Receptors and BDNF Regulation: Implications for Psychopathology

       • Minal Jaggar, Vidita A. Vaidya

       Pages 395-438

5-HT2A receptors are G-protein coupled receptors that are widely distributed throughout the brain, most notably on neuronal and glial cells. 5-HT2A receptors have been implicated in various central physiological functions including mood regulation, memory, sleep, nociception, eating, and reward behaviors, and they are also believed to control the cardiovascular system. This  book provides a comprehensive overview of these receptors including sections on their properties and distribution, approaches for their study, their role in a number of brain functions and diseases, and their role as therapeutic targets. ​

• 5HT2A receptors
• G-protein coupled receptors
• neuropsychiatric disorders
• pharmacology
• physiology
• trafficking
• brain
• imaging
• schizophrenia
• Pathophysiology
• eating disorders
• epilepsy

• Faculté de Pharmacie, Université Paris Sud, Université Paris-Saclay, Chatenay-Malabry, France

  Bruno P. Guiard

• Department of Physiology and Biochemistry, University of Malta, Msida MSD, Malta

  Giuseppe Di Giovanni

Giuseppe Di Giovanni is Professor of Human Physiology, University of Malta, Malta. He is the President of the Malta Neuroscience Network and the Vice-President of the Mediterranean Neuroscience Society. He is the Editor in  Chief of Journal Neuroscience Methods by Elsevier and the Editor for the book series The Receptor by Springer/Nature. His research  focuses on the pathophysiology of the monoaminergic systems in different neuropsychiatric disorders, such as Parkinson's disease, depression, drug of abuse and epilepsy.

Bruno Guiard is Associate Professor in Pharmacology, University of Paris XI, France. He is the author of several book chapters/reviews on the mechanisms of action of antidepressant drugs. He also took part in the edition of books on the neurobiology of mood. His research deals with the influence of astroglial cells in the regulation of serotonergic neurotransmission and the identification of new pharmacological targets for the treatment of various neuropsychiatric diseases. 

Policies and ethics