Abstract
Background/Purpose of the study
Acute upper gastrointestinal (UGI) bleed is a life-threatening emergency carrying risks of rebleed and mortality despite standard pharmacological and endoscopic management. We aimed to determine etiologies of acute UGI bleed in hospitalized patients and outcomes (rebleed rates, 5-day mortality, in-hospital mortality, 6-week mortality, need for surgery) and to determine predictors of rebleed and mortality.
Methods
Clinical and endoscopic findings were recorded in patients aged > 12 years who presented within 72 h of onset of UGI bleed. Outcomes were recorded during the hospital stay and 6 weeks after discharge.
Results
A total of 305 patients were included in this study, mean age being 44 ± 17 years. Most common etiology of UGI bleed was portal hypertension (62.3%) followed by peptic ulcer disease (PUD) (16.7%). Rebleed rate within 6 weeks was 37.4% (portal hypertension 47.9%, PUD 21.6%, malignancy 71.4%). Five-day mortality was 2.3% (malignancy 14.3%, portal hypertension 3.2%); the in-hospital mortality rate was 3.0% (malignancy 14.3%, portal hypertension 3.2%, PUD 0.0%) and 4.9% at 6 weeks (malignancy 28.6%, portal hypertension 5.8%, PUD 0.0%). Surgery was required in 4.59% patients. On multivariate analysis, post-endoscopy Rockall score was significantly predictive of rebleed in both portal hypertension- and PUD-related rebleed. No factors were found predictive of mortality in multivariate analysis.
Conclusion
Portal hypertension remains the commonest cause of UGI bleed in India and carries a higher risk of rebleed and mortality as compared to PUD-related bleed. Post-endoscopy Rockall score is a useful tool for clinicians to assess risk of rebleed.
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References
Roberts SE, Button LA, Williams JG. Prognosis following upper gastrointestinal bleeding. PLoS One. 2012;7:e49507.
Campbell HE, Stokes EA, Bargo D, et al. Costs and quality of life associated with acute upper gastrointestinal bleeding in the UK: cohort analysis of patients in a cluster randomised trial. BMJ Open. 2015;5:e007230.
Gralnek IM, Dumonceau JM, Kuipers EJ, et al. Diagnosis and management of nonvariceal upper gastrointestinal hemorrhage: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy. 2015;47:a1–46.
Hwang JH, Fisher DA, Ben-Menachem T, et al. The role of endoscopy in the management of acute non-variceal upper GI bleeding. Gastrointest Endosc. 2012;75:1132–8.
Garcia-Tsao G, Abraldes JG, Berzigotti A, Bosch J. Portal hypertensive bleeding in cirrhosis: risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the Study of Liver Diseases. Hepatology. 2017;65:310–35.
Dilawari JB, Kaur U, Narayanan VA, et al. Pattern of upper gastrointestinal haemorrhage in northern India – an endoscopic study of 316 patients. J Gastroenterol Hepatol. 1987;2:443–9.
Rao TH, Pande GK, Sahni P, Nundy S. The management of upper gastrointestinal haemorrhage in a tropical country. Arch Emerg Med. 1991;8:169–76.
Singh SP, Panigrahi MK. Spectrum of upper gastrointestinal hemorrhage in coastal Odisha. Trop Gastroenterol. 2013;34:14–7.
Anand D, Gupta R, Dhar M, Ahuja V. Clinical and endoscopic profile of patients with upper gastrointestinal bleeding at tertiary care center of North India. J Dig Endosc. 2014;5:139–43.
Vishnu Prasad NR, Ali SM, Ganapathy V, Sreenath GS, Suresh KS. Acute upper gastrointestinal bleeding in a tertiary care hospital in South India - have we improved the outcomes? Trop Gastroenterol. 2016;37:168–76.
Rockall TA, Logan RFA, Devlin HB, Northfield TC. Risk assessment after acute upper gastrointestinal haemorrhage. Gut. 1996;38:316–21.
Forrest JA, Finlayson ND, Shearman DJ. Endoscopy in gastrointestinal bleeding. Lancet. 1974;2:394–7.
Anand CS, Tandon BN, Nundy S. The causes, management and outcome of upper gastrointestinal haemorrhage in an Indian hospital. Br J Surg. 1983;70:209–11.
van Leerdam ME, Vreeberg EM, Rauws EAJ, et al. Acute upper GI bleeding: did anything change? Time trend analysis of incidence and outcome of acute upper GI bleeding between 1993/1994 and 2000. Am J Gastroenterol. 2003;98:1494–9.
Hearnshaw SA, Logan RFA, Lowe D, Travis SPL, Murphy MF, Palmer KR. Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses and outcomes in the 2007 UK audit. Gut. 2011;60:1327–35.
Wuerth BA, Rockey DC. Changing epidemiology of upper gastrointestinal hemorrhage in the last decade: a nationwide analysis. Dig Dis Sci. 2018;63:1286–93.
Poddar U, Thapa BR, Rao KL, Singh K. Etiological spectrum of esphageal varices due to portal hypertension in Indian children: is it different from the West? J Gastroenterol Hepatol. 2008;23:1354–7.
Goyal S, Dixit VK, Jain AK, Mishra OP, Jena SK, Ghosh J. Revisiting extra hepatic portal vein obstruction in children from the North Indian Gangetic Plain. Indian J Pediatr. 2014;81:429–33.
Jairatha V, Rehal S, Loganc R, et al. Acute variceal haemorrhage in the United Kingdom: patient characteristics, management and outcomes in a nationwide audit. Dig Liver Dis. 2014;46:419–26.
Charatcharoenwitthaya P, Pausawasdi N, Laosanguaneak N, Bubthamala J, Tanwandee T, Leelakusolvong S. Characteristics and outcomes of acute upper gastrointestinal bleeding after therapeutic endoscopy in the elderly. World J Gastroenterol. 2011;17:3724–32.
Elsebaey MA, Elashry H, Elbedewy TA, et al. Predictors of in-hospital mortality in a cohort of elderly Egyptian patients with acute upper gastrointestinal bleeding. Medicine (Baltimore). 2018;97:e0403.
Gupta A, Agarwal R, Ananthakrishnan AN. “Weekend effect” in patients with upper gastrointestinal hemorrhage: a systematic review and meta-analysis. Am J Gastroenterol. 2018;113:13–21.
Rathi P, Abraham P, Jakareddy R, Pai N. Spectrum of upper gastrointestinal bleeding in Western India. Indian J Gastroenterol. 2001;20 Suppl 2:A37.
Kaviani MJ, Pirastehfar M, Azari A, Saber Firoozi M. Etiology and outcome of patients with upper gastrointestinal bleeding: a study from south of Iran. Saudi J Gastroenterol. 2010;16:253–9.
Dewan KR, Patowary BS, Bhattarai S. A study of clinical and endoscopic profile of acute upper gastrointestinal bleeding. Kathmandu Univ Med J. 2014;45:21–5.
Acknowledgments
The authors gratefully acknowledge the assistance and contributions of the following persons at the School of Digestive and Liver Diseases, Institute of Postgraduate Medical Education and Research and SSKM Hospital, Kolkata: (1) Kshaunish Das, Professor, Department of Gastroenterology; (2) Kausik Das, Associate Professor, Department of Hepatology; (3) Rajib Sarkar (RS), Associate Professor, Department of Gastroenterology; and (4) Partha Sarathi Patra (PSP), Associate Professor, Department of Gastroenterology.
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Banerjee, A., Bishnu, S. & Dhali, G.K. Acute upper gastrointestinal bleed: An audit of the causes and outcomes from a tertiary care center in eastern India. Indian J Gastroenterol 38, 190–202 (2019). https://doi.org/10.1007/s12664-018-00930-7
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DOI: https://doi.org/10.1007/s12664-018-00930-7