- AutorIn
- Sophie Degner
- Heinz-Adolf Schoon
- Sebastian Degner
- Mathias Baudis
- Claudia Schandelmaier
- Heike Aupperle-Lellbach
- Sandra Schöninger
- Titel
- Expression of Myoepithelial Markers in Mammary Carcinomas of 119 Pet Rabbits
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-846046
- Quellenangabe
- Animals
Erscheinungsjahr: 2019
Jahrgang: 9
Heft: 10
E-ISSN: 2076-2615
Artikelnummer: 740 - Erstveröffentlichung
- 2019
- Abstract (EN)
- Mammary cancer is a serious health issue in pet rabbits; prognostic factors are unknown. In a normal mammary gland, glandular secretory cells are surrounded by a single continuous layer of myoepithelial cells. In non-invasive mammary carcinomas, tumor cells are delineated by an intact myoepithelial layer, which is gradually lost to invasive carcinomas. The main aim of this study was to determine in rabbit mammary carcinomas (n = 119) the expression of myoepithelial markers that have prognostic significance in human cancer. Results show that all cases contained some retained myoepithelial cells. In 93% of the tumors, neoplastic cells expressed the myoepithelial marker calponin. There was a statistically significant association between higher percentages of calponin-containing cancer cells and histological features indicative of a better tumor differentiation, i.e., a lower proliferation of tumor cells, an increased percentage of tubular growth within the tumor, and a lower tumor grade, respectively. These results suggest that rabbit mammary carcinomas develop from progression of non-invasive cancer forms, and that calponin expression in cancer cells likely represents a favorable prognostic factor. The latter hypothesis has to be confirmed in long-term follow-up studies.
- Andere Ausgabe
- Link zur Erstveröffentlichung
Link: https://doi.org/10.3390/ani9100740 - Freie Schlagwörter (EN)
- calponin; histopathology; immunohistochemistry; mammary carcinoma; myoepithelial cells; Oryctolagus cuniculus; pet rabbit; statistical analysis
- Klassifikation (DDC)
- 590
- Verlag
- MDPI, Basel
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa2-846046
- Veröffentlichungsdatum Qucosa
- 06.04.2023
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
- CC BY 4.0