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Relationship between coronary artery calcium score and bleeding events after percutaneous coronary intervention in chronic coronary syndrome

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Abstract

The relationship between coronary artery calcium (CAC) and bleeding events after percutaneous coronary intervention (PCI) in patients with chronic coronary syndrome (CCS) is not well established. This study aimed to examine the association between CAC scores and clinical outcomes after PCI in patients with CCS. This retrospective observational study included 295 consecutive patients who underwent multidetector computer tomography and were scheduled for their first elective PCI. Patients were categorized into two groups based on the CAC scores (low: ≤ 400 or high: > 400). The bleeding risk was evaluated using the Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria. The primary clinical outcome was a major bleeding event within 1 year after PCI, defined as Bleeding Academic Research Consortium (BARC) 3 or 5. The high CAC score group had a higher proportion of patients meeting the ARC-HBR criteria than the low CAC score group (52.7% vs. 31.3%, p < 0.001). Kaplan–Meier survival analysis showed that the incidence of major bleeding events was higher in the high CAC score group as compared to the low CAC score group (p < 0.001). Furthermore, multivariate Cox regression anal ysis revealed that a high CAC score was an independent determinant of major bleeding events during the first year after PCI. A high CAC score is significantly associated with the incidence of major bleeding events after PCI in CCS patients.

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Data Availability

All data underlying this article will be shared on reasonable request to the corresponding author.

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Acknowledgements

All authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Funding

No specific funding was received for this study.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Miyazaki Prefectural Nobeoka Hospital, 2-1-10 Shinkoji, Nobeoka, Miyazaki, 882-0835, Japan

    Soichi Komaki, Ryota Kaichi, Masafumi Takae, Takayuki Mori, Reiko Toida, Kazumasa Kurogi & Nobuyasu Yamamoto

  2. Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-Ku, Kumamoto, 860-8556, Japan

    Masanobu Ishii & Kenichi Tsujita

  3. Cardiorenal Research Laboratory, Department of Hemo-Vascular Advanced Medicine Faculty of Medicine, University of Miyazaki, 5200 Kiyotakecho Kihara, Miyazaki-City, Miyazaki, 889-1692, Japan

    Soichi Komaki & Toshihiro Tsuruda

  4. Division of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kiyotakecho Kihara, Miyazaki-City, Miyazaki, 889-1692, Japan

    Yunosuke Matsuura & Koichi Kaikita

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  1. Soichi Komaki
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Correspondence to Koichi Kaikita.

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Conflict of interest

Dr. Koichi Kaikita has received remuneration for lectures from Bayer Yakuhin Ltd., Daiichi-Sankyo Co. Ltd., Novartis Pharma AG., and Otsuka Pharmaceutical Co. Ltd.; has received trust research/joint research funds from Bayer Yakuhin Ltd. and Daiichi-Sankyo Co. Ltd.; and has received scholarship funds from Abbott Medical Co. Ltd. Dr. Kenichi Tsujita has received remuneration for lectures from Abbott Medical Co. Ltd., Amgen K.K., AstraZeneca K.K., Bayer Yakuhin Ltd., Daiichi-Sankyo Co. Ltd., Medtronic Japan Co. Ltd., Kowa Pharmaceutical Co. Ltd., Novartis Pharma K.K., Otsuka Pharmaceutical Co. Ltd., Pfizer Japan Inc., and Janssen Pharmaceutical K.K.; has received trust research/joint research funds from PPD-Shin Nippon Biomedical Laboratories K.K. and Alexion Pharmaceuticals Inc.; and has received scholarship funds from Abbott Medical Co. Ltd., Bayer Yakuhin Ltd., Boehringer Ingelheim Japan, Daiichi-Sankyo Co. Ltd., ITI Co. Ltd., ONO PHARMACEUTICAL CO. LTD., Otsuka Pharmaceutical Co. Ltd., and Takeda Pharmaceutical Co. Ltd.

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Komaki, S., Ishii, M., Kaichi, R. et al. Relationship between coronary artery calcium score and bleeding events after percutaneous coronary intervention in chronic coronary syndrome. Heart Vessels 38, 919–928 (2023). https://doi.org/10.1007/s00380-023-02248-7

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