Abstract
Androgen-dependent human prostate adenocarcinoma cell line LNCaP was used to study the effect of androgen deprivation on the cell response to TNF-related cytokines. Several signaling pathways were implicated in cell survival in the absence of androgens. In androgen-deprived LNCaP cells, TNF-α and TRAIL stimulated the cell growth and activated the mitogenic and antiapoptotic signaling pathways involving NF-κB, STAT3, PI3K, and β-catenin. The results suggested a role of cytokines in the survival of prostate adenocarcinoma cells deprived of androgens in vitro.
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Adler, V.V., Polotskaya, A.V., Gershtein, E.S. et al. Signaling Pathways That Control the Growth and Survival of Prostate Carcinoma Cells in the Absence of Androgens. Molecular Biology 37, 585–590 (2003). https://doi.org/10.1023/A:1025143528771
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DOI: https://doi.org/10.1023/A:1025143528771