Distribution and Elimination of Poly (methyl methacrylate) Nanoparticles After Subcutaneous Administration to Rats

doi:10.1002/jps.2600721009

Journal of Pharmaceutical Sciences

Volume 72, Issue 10, October 1983, Pages 1146-1149

https://doi.org/10.1002/jps.2600721009 Get rights and content

Abstract

□ Poly (methyl [l-¹⁴C]methacrylate) nanoparticles were injected subcutaneously into rats. Almost all of the radioactivity stayed at the injection site. After an initial urinary and fecal excretion of ~ 1% of the administered dose per day, the rate of elimination dropped to a low level (~ 0.005%/day via the feces and ~ 0.0005%/day via the urine) within 70 days. After 200 days, the fecal elimination increased exponentially until a > 100-fold increase was observed after 287 days in one rat. After this time, a tendency for an increase in fecal elimination was also observed in the other animals, and the radioactivity in all organs and tissue increased by ~ 100 times in all animals in comparison with the organ radioactivity determinations at earlier times.

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Distribution and Elimination of Poly (methyl methacrylate) Nanoparticles After Subcutaneous Administration to Rats

Abstract

J. Pharm. Sci.

J. Pharm. Sci.

Infect. Immun.

Exp. Cell Biol.

Med. Microbiol. Immunol.

J. Pharm. Sci.

Infect. Immun.