Biochemical and Biophysical Research Communications
Regular ArticleL-Selectin Regulates Actin Polymerisation via Activation of the Small G-Protein Rac2
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Cited by (60)
L-selectin activation regulates Rho GTPase activity via Ca<sup>+2</sup> influx in Sertoli cell line, ASC-17D cells
2020, Biochemical and Biophysical Research CommunicationsRole of L-selectin on leukocytes in the binding of sialic acids on sperm surface during the phagocytosis of sperm in female reproductive tract
2018, Medical HypothesesCitation Excerpt :In addition to mainly mediating leukocytes capturing and rolling on the endothelial cells, L-selectin plays an important role in the activation of multiple biochemical signaling pathways [9,10], such as the mitogen-activated protein kinase (MAPK) cascade [11]. Brenner et al. found that L selectin crosslink ligands can cause the activation of signaling pathways, which are involved in participation with p56, Grb2/Sos, Ras, MAPK and Rac2, transmit the signals that initiated by the L selectin crosslinking into the cells, eventually lead to the generation of superoxide and the changes of cytoskeleton [12]. Our hypothesis is that during the sperm phagocytosis in female reproductive tract, leukocytes identify the sialic acids on the sperm surface through L-selectin which is on leukocytes surface to bind the sperm, followed by activation of downstream phagocytic signaling pathway and serials of intricate physiological responses resembling the leukocytes phagocytize foreign materials, eventually eliminating the sperm (Fig. 1).
L-Selectin - A dynamic regulator of leukocyte migration
2012, European Journal of Cell BiologyCitation Excerpt :In conjunction with its adhesive function, l-selectin mediates outside-in and inside-out signaling in leukocytes. Ligation of l-selectin with antibody or ligand elicits a number of cellular events, including elevated Ca2+ and phosphotyrosine protein levels (Laudanna et al., 1994; Waddell et al., 1995), synthesis of reactive oxygen compounds (Waddell et al., 1994), activation of the mitogen-activated protein kinases extracellular regulated kinase and Jun N-terminal kinase (Brenner et al., 1996, 1997b), and Rac-mediated rearrangements of the actin cytoskeleton (Brenner et al., 1997a). Furthermore, l-selectin triggers the enhanced binding activity of both β1 and β2 integrins (Hwang et al., 1996; Giblin et al., 1997).
Role of c-Abl in L-selectin shedding from the neutrophil surface
2011, Blood Cells, Molecules, and DiseasesCitation Excerpt :TNF-α-converting enzyme (TACE or ADAM-17) was identified as the protease responsible for L-selectin cleavage [27,28]. Crosslinking of L-selectin with anti-L-selectin mAb or stimulation with sialyl Lewis-x under static conditions leads to the activation of a signaling cascade from tyrosine kinase p56lck to Sos, Ras, MAPK, and Rac2 [29,30]. We previously found that L-selectin is shed from the neutrophil surface as a result of the mechanical stimulus stemming from neutrophil rolling on a sialyl Lewis-x coated surface under shear flow [31].
Cytoskeletal interactions with leukocyte and endothelial cell adhesion molecules
2009, Current Topics in Membranes
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