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mGLU Receptors

  • Book
  • © 2017

Overview

Editors:
  1. Richard Teke Ngomba

    1. Neuropharmacology Unit I.N.M. Neuromed, I.N.M. Neuromed, Pozzilli, Italy

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  2. Giuseppe Di Giovanni

    1. Department of Physiology and Biochemistry, University of Malta, Malta, Italy

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  3. Giuseppe Battaglia

    1. Neuropharmacology Unit, I.N.M. Neuromed, Pozzilli, Italy

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  4. Ferdinando Nicoletti

    1. Dipartimento di Fisiologia Umana, Università di Roma, Roma, Italy

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  • Describes basic, pre-clinical, and clinical neuroscience research on mGLU receptors
  • Addresses mGLU receptor role in health an disease
  • Comprehensive overview of recent research
  • Includes supplementary material: sn.pub/extras

Part of the book series: The Receptors (REC, volume 31)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. mGlu5 Signaling: A Target for Addiction Therapeutics?

    • Christina J. Perry, M. Foster Olive, Andrew J. Lawrence
    Pages 1-14

  3. Supraspinal Metabotropic Glutamate Receptors: An Endogenous Substrate for Alleviating Chronic Pain and Related Affective Disorders

    • Francesca Guida, Enza Palazzo, Livio Luongo, Ida Marabese, Vito de Novellis, Sabatino Maione et al.
    Pages 15-31

  4. Metabotropic Glutamate Receptors and Parkinson’s Disease: Basic and Preclinical Neuroscience

    • Paolo Gubellini, Liliya Iskhakova, Yoland Smith, Marianne Amalric
    Pages 33-57

  5. Metabotropic Glutamate 2 (mGlu2) Receptors and Schizophrenia Treatment

    • Javier González-Maeso
    Pages 59-78

  6. mGlu5: A Metabotropic Glutamate Receptor at the Hub of Hippocampal Information Processing, Persistent Synaptic Plasticity, and Long-Term Memory

    • Hardy Hagena, Denise Manahan-Vaughan
    Pages 79-101

  7. Neuroprotective Properties of Glutamate Metabotropic Glutamate Receptors in Parkinson’s Disease and Other Brain Disorders

    • Gunasingh Jeyaraj Masilamoni, Yoland Smith
    Pages 103-127

  8. Structure, Dynamics, and Modulation of Metabotropic Glutamate Receptors

    • Philippe Rondard, Xavier Rovira, Cyril Goudet, Jean-Philippe Pin
    Pages 129-147

  9. Metabotropic Glutamate Receptor Function in Thalamocortical Circuitry

    • Thomas E. Salt, Caroline S. Copeland
    Pages 149-159

  10. Metabotropic Glutamate Receptors in Cancer

    • Lumeng J. Yu, Brian A. Wall, Janet Wangari-Talbot, Suzie Chen
    Pages 161-182

  11. mGlu5 Receptors in Parkinson’s Disease and MPTP-Lesioned Monkeys: Behavior and Brain Molecular Correlates

    • Nicolas Morin, Thérèse Di Paolo
    Pages 183-205

  12. Is There a Future for mGlu5-Positive Allosteric Modulators in Absence Epilepsy? A Comparison with Ethosuximide

    • Gilles van Luijtelaar, Valerio D’Amore, Ines Santolini, Richard T. Ngomba
    Pages 207-224

  13. Regulation of Hippocampal mGluR-Dependent Long-Term Depression by GluA2-Dependent Cofilin-Mediated Actin Remodeling

    • Zhengping Jia, Graham Collingridge
    Pages 225-239

  14. Metabotropic Glutamate Receptors in Amygdala Functions

    • Francesco Ferraguti
    Pages 241-277

  15. Back Matter

    Pages 279-282
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Keywords

About this book

Metabotropic glutamate receptors (mGluRs) are members of the group C family of G-protein-coupled receptors. Eight different mGlu subtypes have been identified and classified into three groups based on amino acid sequence similarity, agonist pharmacology, and the signal transduction pathways to which they couple. They perform a variety of functions in the central and peripheral nervous systems, being involved in learning, memory, anxiety, and the perception of pain. They are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and cerebral cortex, as well as other parts of the bain and peripheral tissues. This volume will focus on the latest research in the role of Group I mGluRs in health and disease.

Editors and Affiliations

  • Neuropharmacology Unit I.N.M. Neuromed, I.N.M. Neuromed, Pozzilli, Italy

    Richard Teke Ngomba

  • Department of Physiology and Biochemistry, University of Malta, Malta, Italy

    Giuseppe Di Giovanni

  • Neuropharmacology Unit, I.N.M. Neuromed, Pozzilli, Italy

    Giuseppe Battaglia

  • Dipartimento di Fisiologia Umana, Università di Roma, Roma, Italy

    Ferdinando Nicoletti

Bibliographic Information

  • Book Title: mGLU Receptors

  • Editors: Richard Teke Ngomba, Giuseppe Di Giovanni, Giuseppe Battaglia, Ferdinando Nicoletti

  • Series Title: The Receptors

  • DOI: https://doi.org/10.1007/978-3-319-56170-7

  • Publisher: Humana Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG 2017

  • Hardcover ISBN: 978-3-319-56168-4Published: 05 September 2017

  • Softcover ISBN: 978-3-319-85842-5Published: 12 June 2018

  • eBook ISBN: 978-3-319-56170-7Published: 22 August 2017

  • Series ISSN: 1048-6909

  • Series E-ISSN: 2524-6488

  • Edition Number: 1

  • Number of Pages: X, 282

  • Number of Illustrations: 2 b/w illustrations, 26 illustrations in colour

  • Topics: Neurosciences

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