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Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature

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Acknowledgements

We thank H-Y Nguyen, L Dörner, J Baron, K Lindenberg, U Lass, and J Meyer for skillful technical assistance and the Genome and Proteome Core Facility, High-Throughput Sequencing Unit of the DKFZ. This work was supported by the German Cancer Aid (110670, 110983), the Else Kröner-Fresenius Foundation (A_60), the DKFZ-HIPO through H033, the Hartmut Hoffmann-Berling International Graduate School (DH), the MD/PhD-program of the University Heidelberg (DH), and the Helmholtz International Graduate School for Cancer Research (UHT).

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Authors and Affiliations

  1. Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany

    Felix Sahm, Daniel Schrimpf & Andreas von Deimling

  2. Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany

    Felix Sahm, Damian Stichel, Daniel Schrimpf & Andreas von Deimling

  3. Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany

    Umut H. Toprak, Daniel Hübschmann, Kortine Kleinheinz, Ivo Buchhalter, Roland Eils & Matthias Schlesner

  4. Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg, Germany

    Daniel Hübschmann & Roland Eils

  5. Department of Pediatric Immunology, Hematology and Oncology, University Hospital Heidelberg, Heidelberg, Germany

    Daniel Hübschmann, Dominik Sturm & Stefan M. Pfister

  6. Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Martin Sill

  7. Genomics and Proteomics Core Facility, Microarray Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Matthias Schick & Melanie Bewerunge-Hudler

  8. McFeeters-Hamilton Centre for Neuro-oncology, Princess Margaret Cancer Centre, Toronto, Canada

    Gelareh Zadeh & Ken Aldape

  9. Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Canada

    Gelareh Zadeh

  10. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada

    Ken Aldape

  11. Division of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany

    Christel Herold-Mende

  12. Heidelberg Center for Personalised Oncology (DKFZ-HIPO), German Cancer Research Center (DKFZ), Heidelberg, Germany

    Katja Beck & Roland Eils

  13. Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Ori Staszewski & Marco Prinz

  14. BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany

    Marco Prinz

  15. Department of Neurosurgery, Tel-Aviv Medical Center, Tel-Aviv, Israel

    Carmit Ben Harosh, Zvi Ram & Rachel Grossman

  16. Division of Pediatric Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany

    Dominik Sturm, David T. W. Jones & Stefan M. Pfister

  17. Institute of Neuropathology, University Hospital Muenster, Muenster, Germany

    Werner Paulus

  18. Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

    Zvi Ram & Rachel Grossman

Authors
  1. Felix Sahm
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  2. Umut H. Toprak
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  3. Daniel Hübschmann
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  4. Kortine Kleinheinz
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  6. Martin Sill
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  7. Damian Stichel
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  8. Matthias Schick
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  9. Melanie Bewerunge-Hudler
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  10. Daniel Schrimpf
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  11. Gelareh Zadeh
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  12. Ken Aldape
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  13. Christel Herold-Mende
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  14. Katja Beck
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  15. Ori Staszewski
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  16. Marco Prinz
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  17. Carmit Ben Harosh
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  18. Roland Eils
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  19. Dominik Sturm
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  20. David T. W. Jones
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  21. Stefan M. Pfister
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  22. Werner Paulus
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  23. Zvi Ram
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  24. Matthias Schlesner
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  25. Rachel Grossman
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  26. Andreas von Deimling
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Corresponding authors

Correspondence to Felix Sahm or Andreas von Deimling.

Additional information

Felix Sahm, Umut H. Toprak, Daniel Hübschmann, Matthias Schlesner, Rachel Grossman, and Andreas von Deimling: shared first/senior authors.

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Sahm, F., Toprak, U.H., Hübschmann, D. et al. Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature. Acta Neuropathol 134, 155–158 (2017). https://doi.org/10.1007/s00401-017-1715-9

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  • DOI: https://doi.org/10.1007/s00401-017-1715-9

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