Abstract
In continuation of our studies on compounds with a resveratrol-based scaffold two compounds with N-containing functional groups have been synthesized and screened for their inhibitory effect on the growth of the human cancer cell lines HT29, 518A2, AsPC-1, BxPC-3, and PC-3. Compound 4, but not 1, demonstrated pronounced in vitro cytotoxicity against all these cancer cell lines, thus making this compound a promising candidate for further preclinical in vivo studies.
Similar content being viewed by others
References
BN Ames (1998) Toxicol Lett 102–103 5 Occurrence Handle10.1016/S0378-4274(98)00269-0
M Murias W Jaeger N Handler T Erker Z Horvath T Szekeres H Nohl L Gille (2005) Biochem Pharmacol 69 903 Occurrence Handle10.1016/j.bcp.2004.12.001 Occurrence Handle1:CAS:528:DC%2BD2MXhvVCiu70%3D
M Murias N Handler T Erker K Pleban G Ecker P Saiko T Szekres W Jaeger (2004) Bioorg Med Chem 12 5571 Occurrence Handle10.1016/j.bmc.2004.08.008 Occurrence Handle1:CAS:528:DC%2BD2cXotF2itb4%3D
S Sale RG Tunstall KC Ruparelia GA Potter WP Steward AJ Gescher (2005) Int J Cancer 115 194 Occurrence Handle10.1002/ijc.20884 Occurrence Handle1:CAS:528:DC%2BD2MXjvFWjs74%3D
A Ding T Adrian (2002) Pancreas 25 71 Occurrence Handle10.1097/00006676-200211000-00024 Occurrence Handle1:CAS:528:DC%2BD3sXkslGksbY%3D
T Hsieh J Wu (1999) Exp Cell Res 249 109 Occurrence Handle10.1006/excr.1999.4471 Occurrence Handle1:CAS:528:DyaK1MXivFOrsro%3D
TC Hsieh Z Wang CV Hamby JM Wu (2005) Biochem Biophys Res Commun 334 223 Occurrence Handle10.1016/j.bbrc.2005.06.073 Occurrence Handle1:CAS:528:DC%2BD2MXmt1aqs70%3D
M Jang L Cai GO Udeani KV Slowing CF Thomas CW Beecher HH Fong NR Farnsworth AD Kinghorn RG Mehta RC Moon JM Pezzuto (1997) Science 275 218 Occurrence Handle10.1126/science.275.5297.218 Occurrence Handle1:CAS:528:DyaK2sXks1Sjtw%3D%3D
Z Dong (2003) Mutat Res 523 145
M Fontecave (1998) Cell Mol Live Sci 54 684 Occurrence Handle1:CAS:528:DyaK1cXkvFKgs7Y%3D Occurrence Handle10.1007/s000180050195
Szekeres T, Handler N, Jaeger W, Murias MA, Erker T (2005) PCT Int Appl:WO2005016860
M Cushman D Nagarathnam D Gopal AK Chakraborti CM Lin E Hamel (1991) J Med Chem 34 2579 Occurrence Handle10.1021/jm00112a036 Occurrence Handle1:CAS:528:DyaK3MXkvFWksLc%3D
Author information
Authors and Affiliations
Corresponding author
Additional information
Correspondence: Thomas Erker, Department of Medicinal Chemistry, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.
Rights and permissions
About this article
Cite this article
Handler, N., Saiko, P., Jaeger, W. et al. Synthesis and cytotoxic activity of resveratrol-based compounds. Monatsh Chem 139, 575–578 (2008). https://doi.org/10.1007/s00706-007-0791-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00706-007-0791-2