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Synthesis and cytotoxic activity of resveratrol-based compounds

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Abstract

In continuation of our studies on compounds with a resveratrol-based scaffold two compounds with N-containing functional groups have been synthesized and screened for their inhibitory effect on the growth of the human cancer cell lines HT29, 518A2, AsPC-1, BxPC-3, and PC-3. Compound 4, but not 1, demonstrated pronounced in vitro cytotoxicity against all these cancer cell lines, thus making this compound a promising candidate for further preclinical in vivo studies.

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Authors and Affiliations

  1. Department of Medicinal Chemistry, University of Vienna, Vienna, Austria

    Norbert Handler, Heinz Berner, Klaus Leisser & Thomas Erker

  2. Clinical Institute for Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria

    Philipp Saiko & Thomas Szekeres

  3. Department of Clinical Pharmacy and Diagnostics, University of Vienna, Vienna, Austria

    Walter Jaeger

  4. Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

    Volker Wacheck

Authors
  1. Norbert Handler
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  2. Philipp Saiko
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  3. Walter Jaeger
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  4. Thomas Szekeres
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  5. Volker Wacheck
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  6. Heinz Berner
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  7. Klaus Leisser
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  8. Thomas Erker
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Corresponding author

Correspondence to Thomas Erker.

Additional information

Correspondence: Thomas Erker, Department of Medicinal Chemistry, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.

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Handler, N., Saiko, P., Jaeger, W. et al. Synthesis and cytotoxic activity of resveratrol-based compounds. Monatsh Chem 139, 575–578 (2008). https://doi.org/10.1007/s00706-007-0791-2

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  • DOI: https://doi.org/10.1007/s00706-007-0791-2

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