Skip to main content

Advertisement

SpringerLink
Log in

Gliosarcoma with bone infiltration and extracranial growth: case report and review of literature

  • Case Report
  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Gliosarcoma is a relatively rare and highly malignant brain tumor consisting of both a glioblastoma and a mesenchymal component. Because of the natural barrier of the dura mater, that prevents intra or extradural neoplasm dissemination, cases of penetration of the dura and cranium by gliosarcomas without previous surgery or radiation are very rarely reported. We report an unusual case of gliosarcoma that involved the temporal skull base and the dura without antecedent radiation or surgery, although the lesion traversed the dura without radiologic or gross interruption of the dura. Remarkable in our case is the initial integrity of cerebral parenchyma. Follow-up revealed a tumorous infiltration of the temporal lobe almost one year after initial diagnosis. Thus the origin of the gliosarcoma in our case seemed to be extradural in the temporal skull base. Furthermore, this report demonstrates that extensive multi-modality treatment might be effective in patients with gliosarcomas and poor prognostic factors, for example unmethylated MGMT status.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Abbreviations

GFAP:

Glial fibrillary acidic protein

EGFR:

Epidermal growth factor receptor

EORTC:

European Organisation for Research and Treatment of Cancer

References

  1. Ohgaki H, Biernat W, Reis R, Hegi M, Kleihues P (2000) Gliosarcoma. In: Kleihues PCW, Cavenee WK (eds) Pathology and genetics of tumours of the central nervous system, vol 2000. World health organization classification of tumours, 2nd edn. IARC Press, Lyon, France, pp 42–44

    Google Scholar 

  2. Lutterbach J, Guttenberger R, Pagenstecher A (2001) Gliosarcoma: a clinical study. Radiother Oncol 61:57–64

    Article  PubMed  CAS  Google Scholar 

  3. Galanis E, Buckner JC, Dinapoli RP, Scheithauer BW, Jenkins RB, Wang CH, O’Fallon JR, Farr G Jr (1998) Clinical outcome of gliosarcoma compared with glioblastoma multiforme: North Central Cancer Treatment Group results. J Neurosurg 89:425–430

    Article  PubMed  CAS  Google Scholar 

  4. Barresi V, Cerasoli S, Morigi F, Cremonini AM, Volpini M, Tuccari G (2006) Gliosarcoma with features of osteoblastic osteosarcoma. A review. Arch Pathol Lab Med 130:1208–1211

    PubMed  Google Scholar 

  5. Lieberman KA, Fuller CE, Caruso RD, Schelper RL (2001) Postradiation gliosarcoma with osteosarcomatous components. Neuroradiology 43:555–558

    Article  PubMed  CAS  Google Scholar 

  6. Shintaku M, Miyaji K, Adachi Y (1998) Gliosarcoma with angiosarcomatous features: a case report. Brain Tumor Pathol 15:101–105

    Article  PubMed  CAS  Google Scholar 

  7. Banerjee AK, Sharma SB, Kak VK, Ghatak NR (1989) Gliosarcoma with cartilage formation. Cancer 63:518–523

    Article  PubMed  CAS  Google Scholar 

  8. Barnard RO, Bradford R, Scott T, Thomas DGT (1986) Gliomyosarcoma: report of a case of rhabdomyosarcoma arising in a malignant glioma. Acta Neuropathol (Berl) 69:23–27

    Article  CAS  Google Scholar 

  9. Vlodavsky EKM, Konstantinesku M, Soustiel JF (2006) Gliosarcoma with liposarcomatous differentiation. The new member of the lipid-containing brain tumors family. Arch Pathol Lab Med 130:381–384

    PubMed  Google Scholar 

  10. Borota OC, Scheie D, Bjerkhagen B, Jacobsen EA, Skullerud K (2006) Gliosarcoma with liposarcomatous component, bone infiltration and extracranial growth. Clin Neuropathol 25(4):200–203

    Google Scholar 

  11. Sade B, Prayson RA, Lee JH (2006) Gliosarcoma with infratemporal fossa extension. J Neurosurg 105:904–907

    Article  PubMed  Google Scholar 

  12. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352(10):987–996. doi:352/10/987[pii]10.1056/NEJMoa043330

    Article  PubMed  CAS  Google Scholar 

  13. Aoyama I, Makita Y, Nabeshima S, Motomochi M, Masuda A (1980) Extradural nasal and orbital extension of glioblastoma multiforme without previous surgical intervention. Surg Neurol 14:343–347

    PubMed  CAS  Google Scholar 

  14. Rubinstein LJ (1967) Development of extracranial metastases from a malignant astrocytoma in the absence of previous craniotomy: case report. J Neurosurg 26:542–547

    Article  PubMed  CAS  Google Scholar 

  15. Schuster H, Jellinger K, Gund A, Regele H (1976) Extracranial metastases of anaplastic cerebral gliomas. Acta Neurochir (Wien) 35:247–259

    Article  CAS  Google Scholar 

  16. Pompili A, Calvosa F, Caroli F, Mastrostefano R, Occhipinti E, Raus L, Sciarretta F (1993) The transdural extension of gliomas. J Neurooncol 15:67–74

    Article  PubMed  CAS  Google Scholar 

  17. Orita T, Nishizaki T, Furutani Y, Aoki H (1989) Extradural nasal and orbital extension of malignant glioma: case report. Surg Neurol 31:395–399

    Article  PubMed  CAS  Google Scholar 

  18. Murphy MN, Korkis JA, Robson FC, Sima AA (1985) Gliosarcoma with cranial penetration and extension to the maxillary sinus. J Otolaryngol 14:313–316

    PubMed  CAS  Google Scholar 

  19. Morantz RA, Feigin I, Ransohoff J (1976) Clinical and pathological study of 24 cases of gliosarcoma. J Neurosurg 45:398–408

    Article  PubMed  CAS  Google Scholar 

  20. Kaschten BFP, Flandroy P, Reznil M, Hainaut H, Stevenaert A (1995) Radiation-induced gliosarcoma. J Neurosurg 83:154–162

    Article  PubMed  CAS  Google Scholar 

  21. Malde R, Jalali R, Muzumdar D, Shet T, Kurkure P (2004) Gliosarcoma occurring 8 years after treatment for a medulloblastoma. Childs Nerv Syst 20:243–246

    Article  PubMed  Google Scholar 

  22. Biernat W, Aguzzi A, Sure U, Grant JW, Kleihues P, Hegi ME (1995) Identical mutations of the p53 tumor suppressor gene in the gliomatous and the sarcomatous components of gliosarcoma suggest a common origin from glial cells. J Neuropathol Exp Neurol 54:651–656

    Article  PubMed  CAS  Google Scholar 

  23. Reis RM, Konu-Lebleblicioglu D, Lopes JM, Kleiheus P, Ohgaki H (2000) Genetic profile of gliosarcomas. Am J Pathol 156:425–432

    Article  PubMed  CAS  Google Scholar 

  24. Meis JM, Martz KL, Nelson JS (1991) Mixed glioblastoma multiforme and sarcoma. A clinicopathologic study of 26 radiation therapy oncology group cases. Cancer 67:2342–2349

    Article  PubMed  CAS  Google Scholar 

  25. Kawano N, Yada K, Ogawa Y, Sasaki K (1977) Spontaneous transdural extension of malignant astrocytoma. J Neurosurg 47:766–770

    Article  PubMed  CAS  Google Scholar 

  26. Shenoy SN, Raja A (2005) Spontaneous transdural spread of glioblastoma with atypical presentation. Br J Neurosurg 19(1):61–65

    Google Scholar 

  27. Sanerkin N (1962) Transdural spread of glioblastoma multiforme. J Pathol Bacteriol 84:228–233

    Article  PubMed  CAS  Google Scholar 

  28. Kang SH, Park KJ, Kim CY, Yu MO, Park CK, Park SH, Chung YG (2010) O(6)-methylguanine DNA methyltransferase status determined by promoter methylation and immunohistochemistry in gliosarcoma and their clinical implications. J Neurooncol. doi:10.1007/s11060-010-0267-9

  29. Prados MD, Chang SM, Butowski N, DeBoer R, Parvataneni R, Carliner H, Kabuubi P, Ayers-Ringler J, Rabbitt J, Page M, Fedoroff A, Sneed PK, Berger MS, McDermott MW, Parsa AT, Vandenberg S, James CD, Lamborn KR, Stokoe D, Haas-Kogan DA (2009) Phase ii study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma. J Clin Oncol 27(4):579–584. doi:JCO.2008.18.9639[pii]10.1200/JCO.2008.18.9639

    Article  PubMed  CAS  Google Scholar 

  30. Wen PY, Fine HA, Black PM, Shrieve DC, Alexander E III, Loeffler JS (1995) High-grade astrocytomas. Neurol Clin 13(4):875–900

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Johann Wolfgang Goethe-University Frankfurt am Main, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany

    Patrick Schuss, Christian T. Ulrich, Volker Seifert & Kea Franz

  2. Institute of Neurology (Edinger Institute), Johann Wolfgang Goethe-University Frankfurt am Main, Heinrich-Hoffmann-Strasse 7, 60528, Frankfurt am Main, Germany

    Patrick N. Harter & Dominique S. Tews

Authors
  1. Patrick Schuss
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christian T. Ulrich
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Patrick N. Harter
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dominique S. Tews
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Volker Seifert
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kea Franz
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Patrick Schuss.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schuss, P., Ulrich, C.T., Harter, P.N. et al. Gliosarcoma with bone infiltration and extracranial growth: case report and review of literature. J Neurooncol 103, 765–770 (2011). https://doi.org/10.1007/s11060-010-0437-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11060-010-0437-9

Keywords

Search

Navigation