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Laboratory Support of Global Health Research

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ABSTRACT

Laboratory generated data are used in support of several types of global health research. Routinely obtained clinical diagnostic data are used for disease surveillance, epidemiologic analysis of frequencies and trends, health outcomes research, and sponsored research projects. Clinical data from research laboratories is also collected in support of sponsored research projects. Whether the initial purpose of the testing is in support of research protocols or the data are retrospectively reviewed, the quality of the laboratory data is essential to drawing correct conclusions. The types and use of data generated by on-site, routine diagnostic, research diagnostic and basic science laboratories will be described, with a focus on quality-related issues. Full integration of laboratory management as a partner is essential to successful research planning and execution.

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REFERENCES

  1. Martin R, Hearn TL, Ridderhof JC, Demby A. Implementation of a quality systems approach for laboratory practice in resource-constrained countries. AIDS. 2005;19:S59–65.

    Article  PubMed  Google Scholar 

  2. McDougal JS, Pilcher CD, Parekh BS, et al. Surveillance for HIV-1 incidence using tests for recent infection in resource-constrained countries. AIDS. 2005;19:S25–30.

    Article  PubMed  Google Scholar 

  3. Franco-Paredes C, Tellez I, del Rio C. Rapid HIV testing: a review of the literature and implications for the clinician. Curr HIV/AIDS Rep. 2006;3(4):169–75.

    Article  PubMed  Google Scholar 

  4. Ginsburg AS, Miller A, Wilfert CM. Diagnosis of pediatric Human Immunodeficiency Virus infection in resource-constrained settings. Pediatr Infect Dis J. 2006;25(11):1057–64.

    Article  PubMed  Google Scholar 

  5. Birx D, de Souza M, Nkengasong JN. Laboratory challenges in the scaling up of HIV, TB, and malaria programs. Am J Clin Pathol. 2009;131(6):849–51.

    Article  PubMed  Google Scholar 

  6. Dieye TN, Vereecken C, Diallo AA, et al. Absolute CD4 T-cell counting in resource-poor settings: direct volumetric measurements versus bead-based clinical flow cytometry instruments. JAIDS J Acquir Immune Defic Syndr. 2005;39(1):32–7.

    Article  Google Scholar 

  7. Crowe S, Turnbull S, Oelrichs R, Dunne A. Monitoring of Human Immunodeficiency Virus infection in resource-constrained countries. Clin Infect Dis. 2003;37(Supplement 1):S25–35.

    Article  PubMed  Google Scholar 

  8. Getahun H, Harrington M, O’Brien R, Nunn P. Diagnosis of smear-negative pulmonary tuberculosis in people with HIV infection or AIDS in resource-constrained settings: informing urgent policy changes. Lancet. 2007;369(9578):2042–9.

    Article  PubMed  Google Scholar 

  9. Peter T, Badrichani A, Wu E, et al. Challenges in implementing CD4 testing in resource-limited settings. Cytometry B Clin Cytom. 2008;74B(S1):S123–30.

    Article  Google Scholar 

  10. Srisuwanvilai L-O, Monkongdee P, Podewils LJ, et al. Performance of the BACTEC MGIT 960 compared with solid media for detection of Mycobacterium in Bangkok, Thailand. Diagn Microbiol Infect Dis. 2008;61(4):402–7.

    Article  PubMed  CAS  Google Scholar 

  11. Dorman SE. New diagnostic tests for tuberculosis: bench, bedside, and beyond. Clin Infect Dis. 2010;50(Supplement 3):S173–7.

    Article  PubMed  Google Scholar 

  12. Harris E. Building scientific capacity in developing countries. EMBO Rep. 2004;5:7–11.

    Article  PubMed  CAS  Google Scholar 

  13. Olmsted SS, Moore M, Meili RC, et al. Strengthening laboratory systems in resource-limited settings. Am J Clin Pathol. 2010;134(3):374–80.

    Article  PubMed  Google Scholar 

Download references

Conflict of Interest

Dr. Van Der Pol has consulted for, received honoraria from, or performed research sponsored by the sponsors: Abbott Molecular Diagnostics, BD Diagnostics, Beckman Coulter, Cepheid, and Roche Diagnostics.

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Authors and Affiliations

  1. Department of Epidemiology & Biostatistics, Indiana University School of Public Health, 1025 E Seventh Street, C102, Bloomington, IN, 47405, USA

    Barbara Van Der Pol PhD, MPH

  2. Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN, USA

    Barbara Van Der Pol PhD, MPH

Authors
  1. Barbara Van Der Pol PhD, MPH
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Correspondence to Barbara Van Der Pol PhD, MPH.

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Van Der Pol, B. Laboratory Support of Global Health Research. J GEN INTERN MED 28 (Suppl 3), 654–659 (2013). https://doi.org/10.1007/s11606-013-2458-5

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  • DOI: https://doi.org/10.1007/s11606-013-2458-5

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