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Successful transplantation of ethnically mismatched cord blood in a boy with atypical chronic myeloid leukemia

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Abstract

In the present study, we describe unrelated umbilical cord blood transplantation (CBT) in a 7-year-old Taiwanese boy with atypical chronic myeloid leukemia (BCR-ABL 1 negative). Physical examination was notable for splenomegaly. Cytogenetic analyses from the bone marrow revealed a t(3;5)(p21;q31) translocation. The patient then underwent CBT from an HLA-mismatched (two loci by serotype, three loci by genotype) unrelated donor of Caucasian origin. Times to neutrophil and platelet engraftment were 21 and 62 days post-transplant, respectively. Acute graft-versus-host disease following transplantation was minimal. The patient remains in continuing hematological remission with full donor chimerism 28 months after transplantation.

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Acknowledgments

This work was supported by the research grand CMRPG4A0031 from Chang Gung Memorial Hospital.

Conflict of interest

The authors have no conflicts of interests or funding to disclose.

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Authors and Affiliations

  1. Division of Hematology and Oncology, Department of Pediatrics, Chang Gung Children’s Hospital, Chang Gung University, 5 Fu-Shin Street, Kwei-Shan, 333, Taoyuan, Taiwan

    Tang-Her Jaing, Iou-Jih Hung & Shih-Hsiang Chen

  2. Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Chang Gung Children’s Hospital, Chang Gung University, Taoyuan, Taiwan

    Wen-I Lee

  3. Department of Nursing, Chang Gung University and Memorial Hospital, Taoyuan, Taiwan

    Yu-Chuan Wen & En-Chen Fang

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  1. Tang-Her Jaing
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  2. Iou-Jih Hung
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  4. Wen-I Lee
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  5. Yu-Chuan Wen
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Correspondence to Tang-Her Jaing.

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Jaing, TH., Hung, IJ., Chen, SH. et al. Successful transplantation of ethnically mismatched cord blood in a boy with atypical chronic myeloid leukemia. Int J Hematol 97, 144–146 (2013). https://doi.org/10.1007/s12185-012-1251-2

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  • DOI: https://doi.org/10.1007/s12185-012-1251-2

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