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Topical treatment with propranolol gel as a supplement to the existing treatment of hemangiomas

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Abstract

Background

Systemic treatment with propranolol is proven to be effective for patients with hemangiomas with less side-effect. We used a propranolol gel for topical use on hemangiomas.

Methods

In this retrospective study, we analyzed 148 patients who had been treated topically with propranolol gel for 12 weeks. We analyzed the data of patients and clinically gave each hemangioma a “hemangioma score” to determine the treatment success.

Results

In 147 of the 148 patients, strong signs of resolution under treatment included lightening, paling, and less vascularization. The hemangioma score showed a significant decrease during the treatment. Relevant serum levels of propranolol were not found. Adverse effects were rare and not related to propranolol.

Conclusion

Topical treatment with propranolol gel is suitable for specific hemangiomas in addition to cryotherapy and systemic treatment with propranolol.

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Authors and Affiliations

  1. Children’s Hospital Heilbronn, Heilbronn, Germany

    Markus Schneider, Hansjoerg Cremer & Peter Ruef

  2. Hospital Heilbronn, 74074, Heilbronn, Germany

    Andreas Reimer

Authors
  1. Markus Schneider
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  2. Andreas Reimer
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  3. Hansjoerg Cremer
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  4. Peter Ruef
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Correspondence to Markus Schneider.

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Schneider, M., Reimer, A., Cremer, H. et al. Topical treatment with propranolol gel as a supplement to the existing treatment of hemangiomas. World J Pediatr 10, 313–317 (2014). https://doi.org/10.1007/s12519-014-0509-6

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  • DOI: https://doi.org/10.1007/s12519-014-0509-6

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