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The Effects of Coenzyme Q10 Supplementation on Blood Pressures Among Patients with Metabolic Diseases: A Systematic Review and Meta-analysis of Randomized Controlled Trials

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Abstract

Introduction

Although several trials have assessed the effect of coenzyme Q10 (CoQ10) supplementation on blood pressures among patients with metabolic diseases, findings are controversial.

Aim

This review of randomized controlled trials (RCTs) was performed to summarize the evidence on the effects of CoQ10 supplementation on blood pressures among patients with metabolic diseases.

Methods

Randomized-controlled trials (RCTs) published in PubMed, EMBASE, Web of Science and Cochrane Library databases up to 10 August 2017 were searched. Two review authors independently assessed study eligibility, extracted data, and evaluated risk of bias of included studies. Heterogeneity was measured with a Q-test and with I2 statistics. Data were pooled by using the fix or random-effect model based on the heterogeneity test results and expressed as standardized mean difference (SMD) with 95% confidence interval (CI).

Results

A total of seventeen randomized controlled trials (684 participants) were included. Results showed that CoQ10 supplementation significantly decreased systolic blood pressure (SBP) (SMD − 0.30; 95% CI − 0.52, − 0.08). However, CoQ10 supplementation decreased diastolic blood pressure (DBP), but this was not statistically significant (SMD − 0.08; 95% CI − 0.46, 0.29).

Conclusions

CoQ10 supplementation may result in reduction in SBP levels, but did not affect DBP levels among patients with metabolic diseases. Additional prospective studies regarding the effect of CoQ10 supplementation on blood pressure in patients with metabolic diseases are necessary.

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Author information

Authors and Affiliations

  1. Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran

    Reza Tabrizi & Maryam Akbari

  2. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran

    Nasrin Sharifi, Mohsen Taghizadeh & Zatollah Asemi

  3. Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran

    Kamran B. Lankarani

  4. Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Islamic Republic of Iran

    Mahmood Moosazadeh

  5. Indigenous and Global Health Research, Department of Medicine, University of Alberta, Edmonton, Canada

    Fariba Kolahdooz

Authors
  1. Reza Tabrizi
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  2. Maryam Akbari
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  3. Nasrin Sharifi
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  4. Kamran B. Lankarani
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  5. Mahmood Moosazadeh
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Correspondence to Zatollah Asemi.

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Funding

The current study was founded by a grant from the Vice-chancellor for Research, Shiraz University of Medical Sciences, Shiraz, and Iran.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Tabrizi, R., Akbari, M., Sharifi, N. et al. The Effects of Coenzyme Q10 Supplementation on Blood Pressures Among Patients with Metabolic Diseases: A Systematic Review and Meta-analysis of Randomized Controlled Trials. High Blood Press Cardiovasc Prev 25, 41–50 (2018). https://doi.org/10.1007/s40292-018-0247-2

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