Mycoepoxydiene represents a novel class of fungal metabolites
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Cited by (37)
Oxygen-bridged cyclooctadienes and other polyketides from the mangrove endophytic fungus Diaporthe sp. ZJHJYZ-1
2024, Journal of Molecular StructureAntitumor and immunomodulatory compounds from fungi
2021, Encyclopedia of MycologyBioactive oxygen-bridged cyclooctadienes from endophytic fungus Phomopsis sp. BCC 45011
2015, TetrahedronCitation Excerpt :Mycoepoxydiene (1) was the first compound in this class reported so far. It was first isolated from a fungus OS-F66617 in 19991 and has been reported to have antimicrobial and anticancer activities.2–4 Other compounds in this family include deacetylmycoepoxydiene (2) and 2,3-dihydro mycoepoxydiene from the endophytic fungus Phomopsis sp.
Deacetyl-mycoepoxydiene, isolated from plant endophytic fungi Phomosis sp. demonstrates anti-microtubule activity in MCF-7 cells
2015, Biomedicine and PharmacotherapyCitation Excerpt :HLY-1, which is found in submerged, rotting leaves of Kandelia candel in the mangrove forest in Fujian Province, China [18]. This compound shows similar cytotoxicity to human tumor cell lines with an IC50 ranging from 2.4 to 21.5 μM [8,19,20]. Treatment with mycoepoxydiene leads to a series of cellular events that includes cytoskeletal rearrangement and cell cycle arrest at the G2/M phase.
A rapid and sensitive LC-MS/MS assay for the quantitation of deacetyl mycoepoxydiene in rat plasma with application to preclinical pharmacokinetics studies
2012, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :A123. It was first isolated in 2003 [1–5]. Appropriate analytical method is an urgent need to study its pharmacokinetics in vivo.
Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells
2010, Bioorganic and Medicinal Chemistry Letters