Clinical ResearchHeart Rhythm DisordersCommon Variation in the NOS1AP Gene Is Associated With Drug-Induced QT Prolongation and Ventricular Arrhythmia
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The DARE study was funded by the British Heart Foundation (BHF), Project Grant No. 06/094 (to Dr. Jamshidi) and Special Program Grant No. SP/02/001 (to Dr. Camm). The Vanderbilt study was supported by Grant No. U01/U19 HL65962, the Pharmacogenomics of Arrhythmia Therapy site of the Pharmacogenomics Research Network, and by a grant from the Fondation Leducq (Trans-Atlantic Network of Excellence “Alliance Against Sudden Cardiac Death,” 05 CVD 01). The BRIGHT study was supported by the Medical Research Council of Great Britain (Grant No. G9521010D) and by BHF Grant No. PG/02/128. Genotyping for the Human_CVD BeadChip was supported by BHF Grant No. PG/07/131/24254 (to Dr. Munroe). This work forms part of the research themes contributing to the translational research portfolio for Barts and the London Cardiovascular Biomedical Research Unit, which is supported and funded by the National Institute for Health Research. Dr. Johnson has received research funding from Wellcome Trust (Grant No. 093078/Z/10/Z); and is an employee of GlaxoSmithKline. Dr. George has received research grants from Gilead Sciences and Allergan Inc. Dr. Camm is an advisor and speaker for Boehringer Ingelheim, Bayer, Daiichi, Pfizer, Bristol-Myers Squibb, Sanofi, Servier, Xention, Medtronic, Boston Scientific, Gilead, and Menarini; is a data and safety monitoring board member for Cameron Health, Biotronik, Novartis, Astellas, Forest Labs, Servier, and Bioctcontrol; is an events committee member for Novartis; has research contracts with Sanofi, Boehringer Ingelheim, Daiichi, Menarini, Richmond Pharmacology; and is a consultant for Cardialysis. Dr. Roden has received consulting fees from Astellas, Sanofi, and Warner-Chicott. Dr. Behr has received research funding from Biotronik, the International Serious Adverse Events Consortium, and St. Jude Medical. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Drs. Jamshidi and Nolte contributed equally to this paper.