Elsevier

Tetrahedron Letters

Volume 57, Issue 43, 26 October 2016, Pages 4863-4865
Tetrahedron Letters

Bafilomycin M, a new cytotoxic bafilomycin produced by a Streptomyces sp. isolated from a marine sponge Theonella sp.

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Highlights

  • •

    A new bafilomycin, bafilomycin M, is produced from a Streptomyces sp. GIC10-1.

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    Structure of bafilomycin M was established by interpretation of spectroscopic data.

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    Bafilomycin M showed cytotoxicity against K562, HL-60, SUPT-1, and LNCaP cells.

Abstract

A new 16-membered diene macrolide, bafilomycin M (1), was produced from a Streptomyces sp. GIC10-1, which was originally isolated from a marine sponge Theonella sp. The structure of 1 was established by spectroscopic methods and this compound was found to exhibit cytotoxicity toward K-562, HL-60, SUPT-1, and LNCaP tumor cells with IC50 values 0.060, 0.011, 0.047, and 0.389 μg/mL, respectively.

Section snippets

Acknowledgments

This research was supported by grants from the National Museum of Marine Biology and Aquarium; the National Dong Hwa University; the National Sun Yat-sen University; the Ministry of Science and Technology (Grant No. MOST 103-2320-B-291-001-MY3, 104-2320-B-291-001-MY3, and 105-2325-B-291-001); the National Health Research Institutes (NHRI-EX103-10241BI); and in part by a grant from the Chinese Medicine Research Center, China Medical University (Ministry of Education, Aim for the Top University

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