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Calcium-modulating cyclophilin ligand does not restrict retrovirus release

Nature Medicine volume 16, pages 155–156 (2010)Cite this article

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To the Editor:

The HIV-1 accessory protein Vpu is required for efficient viral release from certain cell lines (termed nonpermissive) but not from others (termed permissive). Neil et al.1 showed that restricted viral release in nonpermissive cells is due to expression of the cellular protein tetherin (also called BST2, CD317 or HM1.24), which tethers viral particles to the cell surface by an unknown mechanism. Tetherin-dependent sequestration of viral particles is counteracted by Vpu1, in a process that is species specific2,3,4,5,6 and seems to encompass Vpu-mediated targeting of tetherin for degradation2,7. Therefore, a precise understanding of how tetherin inhibits viral release and how this release-restricting activity is counteracted by Vpu might identify new targets for antiviral intervention.

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Figure 1: Expression of CAML does not correlate with a nonpermissive release phenotype.
Figure 2: Tetherin but not CAML restricts release of infectious MLV and HIV-1.

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Acknowledgements

We thank T.F. Schulz and F. Kirchhoff for support and R.J. Bram (Mayo Clinic) for CAML-specific antibody. This work was supported by a grant from the German AIDS Society to S. Pöhlmann and G. Behrens and a fellowship from Hannover Biomedical Research School to A. Kühl. The funders were not involved in the design and conduct of the study, in the collection, analysis and interpretation of the data, or in the preparation, review or approval of the manuscript.

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Authors and Affiliations

  1. Institute of Virology, Hannover Medical School, Hannover, Germany

    Annika Kühl, Stephanie Bertram, Ilona Glowacka, Imke Steffen & Stefan Pöhlmann

  2. Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany

    Annika Kühl & Georg Behrens

  3. Institute of Virology, University Clinic of Ulm, Ulm, Germany

    Jan Münch, Daniel Sauter & Anke Specht

  4. Institute of Clinical and Molecular Virology, University Hospital Erlangen-Nürnberg, Erlangen, Germany

    Heike Hofmann

  5. Institute for Physiological Chemistry, Hannover Medical School, Hannover, Germany

    Heike Schneider

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  1. Annika Kühl
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Correspondence to Stefan Pöhlmann.

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Kühl, A., Münch, J., Sauter, D. et al. Calcium-modulating cyclophilin ligand does not restrict retrovirus release. Nat Med 16, 155–156 (2010). https://doi.org/10.1038/nm0210-155

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