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Clinical genetics in 2014

New monogenic diseases span the immunological disease continuum

Nature Reviews Rheumatology volume 11, pages 67–68 (2015)Cite this article

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Three monogenic diseases, with features of both autoinflammation and autoimmunity, were described for the first time in 2014. As well as providing insights into the molecular basis of several rare immunological disorders, the discoveries have implications for their diagnosis and treatment.

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Figure 1: Autoinflammatory and autoimmune features of three new monogenic diseases.

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Acknowledgements

The authors' work is supported by NIHR-LMBRU. The authors apologise to colleagues whose work could not be cited because of space constraints.

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Authors and Affiliations

  1. National Institute for Health Research–Leeds Musculoskeletal Biomedical Research Unit (NIHR-LMBRU), Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), Wellcome Trust Brenner Building, St James University, Beckett Street, Leeds, LS9 7TF, UK

    Sinisa Savic & Michael F. McDermott

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  1. Sinisa Savic
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  2. Michael F. McDermott
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Correspondence to Michael F. McDermott.

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The authors declare no competing financial interests.

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Savic, S., McDermott, M. New monogenic diseases span the immunological disease continuum. Nat Rev Rheumatol 11, 67–68 (2015). https://doi.org/10.1038/nrrheum.2014.215

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