Issue 3, 2011
From the journal:

Organic & Biomolecular Chemistry

Klysimplexins I–T, eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex†

Bo-Wei Chen,a   Chih-Hua Chao,a   Jui-Hsin Su,b   Chung-Wei Tsai,c   Wei-Hsien Wang,ab   Zhi-Hong Wen,a   Chiung-Yao Huang,a   Ping-Jyun Sung,ab   Yang-Chang Wuc  and  Jyh-Horng Sheu*ad  

* Corresponding authors

a Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan

b Taiwan Coral Research Center, National Museum of Marine Biology & Aquarium, Checheng, Taiwan

c Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan

d Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan

Abstract

New eunicellin-base diterpenoids, klysimplexins I–T (1–12), were isolated from a cultured soft coral Klyxum simplex. Their structures were elucidated by spectroscopic methods, particularly in 1D and 2D NMR experiments. The absolute stereochemistry of 4 was determined by Mosher's method. Compounds 9 and 12 have been shown to exhibit cytotoxicity toward a limited panel of cancer cell lines. Compounds 2–6, 10 and 11 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compounds 10 and 11 also could effectively reduce the level of COX-2 protein.

Graphical abstract: Klysimplexins I–T, eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex

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Article information

DOI
https://doi.org/10.1039/C0OB00351D
Article type
Paper
Submitted
30 Jun 2010
Accepted
06 Oct 2010
First published
25 Nov 2010

Org. Biomol. Chem., 2011,9, 834-844

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Klysimplexins I–T, eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex

B. Chen, C. Chao, J. Su, C. Tsai, W. Wang, Z. Wen, C. Huang, P. Sung, Y. Wu and J. Sheu, Org. Biomol. Chem., 2011, 9, 834 DOI: 10.1039/C0OB00351D

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