Issue 9, 2011
From the journal:

Organic & Biomolecular Chemistry

Hirsutosterols A–G, polyoxygenated steroids from a Formosan soft coral Cladiella hirsuta†

Bo-Wei Chen,a   Shu-Ming Chang,a   Chiung-Yao Huang,a   Jui-Hsin Su,b   Zhi-Hong Wen,a   Yang-Chang Wuc  and  Jyh-Horng Sheu*ad  

* Corresponding authors

a Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan
E-mail: sheu@mail.nsysu.edu.tw
Fax: +886-7-5255020
Tel: +886-7-5252000, ext. 5030

b Taiwan Coral Research Center, National Museum of Marine Biology & Aquarium, Checheng, Pingtung, Taiwan

c Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan

d Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung, Taiwan

Abstract

Seven new polyoxygenated steroids, hirsutosterols A–G (1–7), were isolated from the Formosan soft coral Cladiella hirsuta. Their structures were elucidated by spectroscopic methods, particularly in 1D and 2D NMR experiments. The absolute configurations of 1 and 5 were determined by Mosher's method. Sterols 4–6 possess hydroxy groups at C-9 and C-11 and might be oxidatively cleaved to the corresponding 9,11-secosterols. Hirsutosterol A (1) was found to exhibit a stronger cytotoxicity against a limited panel of cancer cell lines.

Graphical abstract: Hirsutosterols A–G, polyoxygenated steroids from a Formosan soft coral Cladiella hirsuta

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Article information

DOI
https://doi.org/10.1039/C1OB05106G
Article type
Paper
Submitted
20 Jan 2011
Accepted
24 Feb 2011
First published
25 Feb 2011

Org. Biomol. Chem., 2011,9, 3272-3278

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Hirsutosterols A–G, polyoxygenated steroids from a Formosan soft coral Cladiella hirsuta

B. Chen, S. Chang, C. Huang, J. Su, Z. Wen, Y. Wu and J. Sheu, Org. Biomol. Chem., 2011, 9, 3272 DOI: 10.1039/C1OB05106G

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