Issue 33, 2013
From the journal:

Chemical Communications

Tabun scavengers based on hydroxamic acid containing cyclodextrins†

Florian Brandhuber,a   Michael Zengerle,b   Luzian Porwol,b   Anne Bierwisch,a   Marianne Koller,a   Georg Reiter,a   Franz Woreka  and  Stefan Kubik*b  

* Corresponding authors

a Institut für Pharmakologie und Toxikologie der Bundeswehr, Neuherbergstraße 11, D-80937 München, Germany

b Fachbereich Chemie – Organische Chemie, Technische Universität Kaiserslautern, Erwin-Schrödinger-Straße, D-67663 Kaiserslautern, Germany
E-mail: kubik@chemie.uni-kl.de
Fax: +49-631-205-3921

Abstract

Arrangement of several hydroxamic acid-derived substituents along the cavity of a cyclodextrin ring leads to compounds that detoxify tabun in TRIS-HCl buffer at physiological pH and 37.0 °C with half-times as low as 3 min.

Graphical abstract: Tabun scavengers based on hydroxamic acid containing cyclodextrins

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Article information

DOI
https://doi.org/10.1039/C3CC41290C
Article type
Communication
Submitted
19 Feb 2013
Accepted
06 Mar 2013
First published
06 Mar 2013

Chem. Commun., 2013,49, 3425-3427

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Tabun scavengers based on hydroxamic acid containing cyclodextrins

F. Brandhuber, M. Zengerle, L. Porwol, A. Bierwisch, M. Koller, G. Reiter, F. Worek and S. Kubik, Chem. Commun., 2013, 49, 3425 DOI: 10.1039/C3CC41290C

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