Issue 53, 2013
From the journal:

Chemical Communications

A generic strategy for pharmacological caging of growth factors for tissue engineering†

Maria Karlsson,ab   Philipp S. Lienemann,cd   Natallia Sprossmann,ae   Katharina Heilmann,f   Tilman Brummer,efg   Matthias P. Lutolf,d   Martin Ehrbarc  and  Wilfried Weber*abef  

* Corresponding authors

a Faculty of Biology, University of Freiburg, Schänzlestrasse 1, 79104 Freiburg, Germany
E-mail: wilfried.weber@biologie.uni-freiburg.de
Fax: +49 761 203 97660
Tel: +49 761 203 97654

b Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland

c Department of Obstetrics, University Hospital Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland

d Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Station 15, Bld AI 1109, 1015 Lausanne, Switzerland

e BIOSS – Centre for Biological Signalling Studies, University of Freiburg, Schänzlestrasse 18, 79104 Freiburg, Germany

f ZBSA – Center for Biological Systems Analysis, University of Freiburg, Habsburgerstrasse 49, 79104 Freiburg, Germany

g Institute for Molecular Medicine and Cell Research, Stefan-Meier-Strasse 17, 79104 Freiburg, Germany

Abstract

The caging of small molecules has revolutionized biological research by providing a means to regulate a wide range of processes. Here we report on a generic pharmacological method to cage proteins in a similar fashion. The present approach is of value in both fundamental and applied research, e.g. in tissue engineering.

Graphical abstract: A generic strategy for pharmacological caging of growth factors for tissue engineering

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Article information

DOI
https://doi.org/10.1039/C3CC41616J
Article type
Communication
Submitted
03 Mar 2013
Accepted
12 May 2013
First published
14 May 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2013,49, 5927-5929

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A generic strategy for pharmacological caging of growth factors for tissue engineering

M. Karlsson, P. S. Lienemann, N. Sprossmann, K. Heilmann, T. Brummer, M. P. Lutolf, M. Ehrbar and W. Weber, Chem. Commun., 2013, 49, 5927 DOI: 10.1039/C3CC41616J

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