Journal of Biological Chemistry
Protein Synthesis and DegradationA structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome
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This work was supported in part by Secretaría de Estado de Investigación, Desarrollo e Innovación Grants BFU2015-64487-R, MDM-2014-0435, and BIO2013-49320-EXP ; Narodowe Centrum Nauki Grants 2015/17/B/NZ1/00666 , “Mobility Plus” 1306/MOB/IV/2015/0, 2012/04/A/NZ1/00051, and 2016/21/B/NZ1/00292; Ministerstwo Nauki i Szkolnictwa Wyższego Grant 2975/7.PR/13/2014/2 ; Seventh Framework Programme Grant FP7-HEALTH-2012-306029-2 “TRIGGER”; Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya Grant 2014SGR9 ; National Institute of Dental and Craniofacial Research, National Institutes of Health Grant R21DE026280 ; Spanish Ministry for Economy and Competitiveness “Juan de la Cierva” Research Contract JCI-2012-13573 (to T. G.); and funding from the European Synchrotron Radiation Facility. The Structural Biology Unit of Molecular Biology Institute of Barcelona is a “María de Maeztu” Unit of Excellence of the Spanish Ministry of Economy, Innovation and Competitiveness. The Faculty of Biochemistry, Biophysics and Biotechnology of the Jagiellonian University is a partner of the Leading National Research Center (KNOW) supported by the Ministry of Science and Higher Education. The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
The atomic coordinates and structure factors (codes 5NCS, 5NCT, 5NCU, and 5NCW) have been deposited in the Protein Data Bank (http://wwpdb.org/).
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Both authors contributed equally to this work.
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Present address: EMBL Outstation Grenoble, 71 Ave. des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France.