Single particle imaging with soft x-rays at the Linac Coherent Light Source

Andrew V. Martin; Jakob Andreasson; Andrew Aquila; Saša Bajt; Thomas R. M. Barends; Miriam Barthelmess; Anton Barty; W. Henry Benner; Christoph Bostedt; John D. Bozek; Phillip Bucksbaum; Carl Caleman; Nicola Coppola; Daniel P. DePonte; Tomas Ekeberg; Sascha W. Epp; Benjamin Erk; George R. Farquar; Holger Fleckenstein; Lutz Foucar; Matthias Frank; Lars Gumprecht; Christina Y. Hampton; Max Hantke; Andreas Hartmann; Elisabeth Hartmann; Robert Hartmann; Stephan P. Hau-Riege; Günther Hauser; Peter Holl; André Hoemke; Olof Jönsson; Stephan Kassemeyer; Nils Kimmel; Maya Kiskinova; Faton Krasniqi; Jacek Krzywinski; Mengning Liang; Ne-Te Duane Loh; Lukas Lomb; Filipe R. N. C. Maia; Stefano Marchesini; Marc Messerschmidt; Karol Nass; Duško Odic; Emanuele Pedersoli; Christian Reich; Daniel Rolles; Benedikt Rudek; Artem Rudenko; Carlo Schmidt; Joachim Schultz; M. Marvin Seibert; Robert L. Shoeman; Raymond G. Sierra; Heike Soltau; Dmitri Starodub; Jan Steinbrener; Francesco Stellato; Lothar Strüder; Martin Svenda; Herbert Tobias; Joachim Ullrich; Georg Weidenspointner; Daniel Westphal; Thomas A. White; Garth Williams; Janos Hajdu; Ilme Schlichting; Michael J. Bogan; Henry N. Chapman

doi:10.1117/12.886754

20 May 2011 Single particle imaging with soft x-rays at the Linac Coherent Light Source

Andrew V. Martin, Jakob Andreasson, Andrew Aquila, Saša Bajt, Thomas R. M. Barends, Miriam Barthelmess, Anton Barty, W. Henry Benner, Christoph Bostedt, John D. Bozek, Phillip Bucksbaum, Carl Caleman, Nicola Coppola, Daniel P. DePonte, Tomas Ekeberg, Sascha W. Epp, Benjamin Erk, George R. Farquar, Holger Fleckenstein, Lutz Foucar, Matthias Frank, Lars Gumprecht, Christina Y. Hampton, Max Hantke, Andreas Hartmann, Elisabeth Hartmann, Robert Hartmann, Stephan P. Hau-Riege, Günther Hauser, Peter Holl, André Hoemke, Olof Jönsson, Stephan Kassemeyer, Nils Kimmel, Maya Kiskinova, Faton Krasniqi, Jacek Krzywinski, Mengning Liang, Ne-Te Duane Loh, Lukas Lomb, Filipe R. N. C. Maia, Stefano Marchesini, Marc Messerschmidt, Karol Nass, Duško Odic, Emanuele Pedersoli, Christian Reich, Daniel Rolles, Benedikt Rudek, Artem Rudenko, Carlo Schmidt, Joachim Schultz, M. Marvin Seibert, Robert L. Shoeman, Raymond G. Sierra, Heike Soltau, Dmitri Starodub, Jan Steinbrener, Francesco Stellato, Lothar Strüder, Martin Svenda, Herbert Tobias, Joachim Ullrich, Georg Weidenspointner, Daniel Westphal, Thomas A. White, Garth Williams, Janos Hajdu, Ilme Schlichting, Michael J. Bogan, Henry N. Chapman

Author Affiliations +

Proceedings Volume 8078, Advances in X-ray Free-Electron Lasers: Radiation Schemes, X-ray Optics, and Instrumentation; 807809 (2011) https://doi.org/10.1117/12.886754
Event: SPIE Optics + Optoelectronics, 2011, Prague, Czech Republic

Abstract

Results of coherent diffractive imaging experiments performed with soft X-rays (1-2 keV) at the Linac Coherent Light Source are presented. Both organic and inorganic nano-sized objects were injected into the XFEL beam as an aerosol focused with an aerodynamic lens. The high intensity and femtosecond duration of X-ray pulses produced by the Linac Coherent Light Source allow structural information to be recorded by X-ray diffraction before the particle is destroyed. Images were formed by using iterative methods to phase single shot diffraction patterns. Strategies for improving the reconstruction methods have been developed. This technique opens up exciting opportunities for biological imaging, allowing structure determination without freezing, staining or crystallization.

Citation Download Citation

Andrew V. Martin, Jakob Andreasson, Andrew Aquila, Saša Bajt, Thomas R. M. Barends, Miriam Barthelmess, Anton Barty, W. Henry Benner, Christoph Bostedt, John D. Bozek, Phillip Bucksbaum, Carl Caleman, Nicola Coppola, Daniel P. DePonte, Tomas Ekeberg, Sascha W. Epp, Benjamin Erk, George R. Farquar, Holger Fleckenstein, Lutz Foucar, Matthias Frank, Lars Gumprecht, Christina Y. Hampton, Max Hantke, Andreas Hartmann, Elisabeth Hartmann, Robert Hartmann, Stephan P. Hau-Riege, Günther Hauser, Peter Holl, André Hoemke, Olof Jönsson, Stephan Kassemeyer, Nils Kimmel, Maya Kiskinova, Faton Krasniqi, Jacek Krzywinski, Mengning Liang, Ne-Te Duane Loh, Lukas Lomb, Filipe R. N. C. Maia, Stefano Marchesini, Marc Messerschmidt, Karol Nass, Duško Odic, Emanuele Pedersoli, Christian Reich, Daniel Rolles, Benedikt Rudek, Artem Rudenko, Carlo Schmidt, Joachim Schultz, M. Marvin Seibert, Robert L. Shoeman, Raymond G. Sierra, Heike Soltau, Dmitri Starodub, Jan Steinbrener, Francesco Stellato, Lothar Strüder, Martin Svenda, Herbert Tobias, Joachim Ullrich, Georg Weidenspointner, Daniel Westphal, Thomas A. White, Garth Williams, Janos Hajdu, Ilme Schlichting, Michael J. Bogan, and Henry N. Chapman "Single particle imaging with soft x-rays at the Linac Coherent Light Source", Proc. SPIE 8078, Advances in X-ray Free-Electron Lasers: Radiation Schemes, X-ray Optics, and Instrumentation, 807809 (20 May 2011); https://doi.org/10.1117/12.886754

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