Journal of Toxicologic Pathology
Online ISSN : 1881-915X
Print ISSN : 0914-9198
ISSN-L : 0914-9198
Reviews
Pathology in Continuous Infusion Studies in Rodents andNon-Rodents and ITO (Infusion Technology Organisation)-Recommended Protocol for Tissue Sampling and Terminology for Procedure-Related Lesions
Klaus Weber, Vasanthi Mowat, Elke Hartmann, Tanja Razinger, Hans-Jörg Chevalier, Kai Blumbach, Owen P. Green, Stefan Kaiser, Stephen Corney, Ailsa Jackson, Agustin Casadesus
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Keywords: continuous infusion, pathology, beagle, non-rodents, rodents, tissue sampling, terminology
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2011 Volume 24 Issue 2 Pages 113-124

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Abstract

Many variables may affect the outcome of continuous infusion studies. The results largely depend on the experience of the laboratory performing these studies, the technical equipment used, the choice of blood vessels and hence the surgical technique as well the quality of pathological evaluation. The latter is of major interest due to the fact that the pathologist is not involved until necropsy in most cases, i.e. not dealing with the complicated surgical or in-life procedures of this study type. The technique of tissue sampling during necropsy and the histology processing procedures may influence the tissues presented for evaluation, hence the pathologist may be a source of misinterpretation. Therefore, ITO proposes a tissue sampling procedure and a standard nomenclature for pathological lesions for all sites and tissues in contact with the port-access and/or catheter system.

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© 2011 The Japanese Society of Toxicologic Pathology
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