Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers
Figure 1
Genome-wide association of hemangiosarcoma and B-cell lymphoma identifies chromosome 5 as a common risk factor.
A. Association of 142 cases with hemangiosarcoma and 172 healthy controls. The inflation factor λ of this analysis is 0.959, indicating that the population stratification had been properly controlled. The observed p-values deviated from the null beyond 95% confidence interval at-logP = 3.84, with a strong peak on chromosome 5, and a few SNPs on other chromosomes reaching significance. B. Analysis of 41 B-cell lymphoma cases and 172 healthy controls (λ = 0.976). C. As both lymphoma and hemangiosarcoma were most strongly associated to the same region on chromosome 5, the datasets were combined (142 hemangiosarcoma + 41 B-cell lymphoma cases and 172 controls) and reanalyzed for association, resulting in an increased association signal on chromosome 5 at p-value of 4.63 × 10−7 (λ = 0.988, significance threshold-logP = 3.66). Sex and the first PC was used as covariates in all association studies.