Preclinical Deposition of Pathological Prion Protein in Muscle of Experimentally Infected Primates
Figure 4
Morphological analysis of tongue reveals PrPSc deposition in nerve fibers and myocytes.
A) Histological analysis of tongue from the clinical, vCJD infected macaque shows muscle fibers intermingled with peripheral nerves (Haematoxilin and Eosin staining, scale bar 50 µm). B, C) PET blot (consecutive section from A) showing labelling of PrPSc. Higher magnification (C) of the insert shown in (B) revealed PrPSc staining of longitudinal nerve fibers (arrow) and adjacent myocytes (triangles).