Pattern of tamoxifen-induced Tie2 deletion in endothelial cells in mature blood vessels using endo SCL-Cre-ERT transgenic mice
Fig 2
Tie2 mRNA and protein expression in control and Tie2 knockout mice.
Tie2 expression levels were determined in organs of Tie2fl/fl/Cre- control mice and Tie2ΔE9 knockout mice after tamoxifen treatment by (A) RT-qPCR, and (B) ELISA. Graphs show individual values and means (black lines) ± SD (error bars). Percent decrease (downward arrow) of Tie2 mRNA or protein in Tie2ΔE9 knockout mice compared to Tie2fl/fl/Cre- controls is indicated under the X-axes. Closed circles: Tie2fl/fl/Cre- mice (n = 8); open circles: Tie2ΔE9 mice (n = 7).