Skip to main content
Log in

The Place of Tramadol in the Therapy of Pain

  • Concluding Remarks
  • Published:
Drugs Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Rashad S, Revell P, Hemingway A, et al. Effect of non-steroidal anti-inflamatory drugs on the course of osteoarthritis. Lancet 1989; 2: 519–22

    Article  PubMed  CAS  Google Scholar 

  2. Zenz M, Willweber-Strumpf A. Opiophobia and cancer pain in Europe. Lancet 1993; 341: 1075–76

    Article  PubMed  CAS  Google Scholar 

  3. Dubner R, Max MB. Antidepressants and the relief of neuropathic pain: evidence for noradrenergic mechanisms. In: Besson J-M, Guilbaud G, editors. Towards the use of noradrenergic agonists for the treatment of pain. 1992: 211–8

    Google Scholar 

  4. Kayser V, Besson J-M, Guilbaud G. Evidence for a noradrenergic component in the antinociceptive effect of the analgesic agent tramadol in an animal model of clinical pain, the arthritic rat. Eur J Pharmacol 1992; 224: 83–8

    Article  PubMed  CAS  Google Scholar 

  5. Raffa RB, Friderichs E, Reimann W, et al. Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an atypical opioid analgesic. J Pharmacol Exp Ther 1992; 260: 275–85

    PubMed  CAS  Google Scholar 

  6. Dayer P. The pharmacology of tramadol. Drugs 1994; 47 Suppl. 1: 3–7

    Article  PubMed  CAS  Google Scholar 

  7. Vickers MD, O’Flaherty D, Szekely SM, et al. Tramadol: pain relief by an opioid without depression of respiration. Anaesthesia 1992; 47: 291–6

    Article  PubMed  CAS  Google Scholar 

  8. Keup W. Missbrauchsmuster bei Abhängigkeit von Alkohol, Medikamenten und Drogen Frühwarnsystem-Daten für die Bundesrepublik Deutschland 1976–1990; Freiburg im Breisgau, Allemagne: Lambertus Verlag, 1993: 48–145

    Google Scholar 

  9. Collart L, Luthy C, Dayer P. Partial inhibition of tramadol antinociceptive effect by naloxone in man. Proceedings of the British Pharmacological Society; 1992 Sep: London. Br J Clin Pharmacol 1993; 35: 73

    Google Scholar 

  10. Desmeules J, Piguet V, Collart L, et al. Contribution of mono-aminergic modulation in tramadol analgesic effect [Abstract]. Clin Pharmacol Ther 1994; 55(2): 151

    Google Scholar 

  11. Raffa RB, Friderichs E, Reimann G, et al. Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol. J Pharmacol Exp Ther 1993; 267(1): 331–40

    PubMed  CAS  Google Scholar 

  12. Lehmann KA. Tramadol for the management of acute pain. Drugs 1994; 47 Suppl. 1: 19–32

    Article  PubMed  Google Scholar 

  13. Göbel H, Stadler TH. Traitement des douleurs post-zostériennes par le tramadol: résultats d’une étude pilote ouverte versus clomipramine avec ou sans lévomépromazine. Drugs 1997; 53 Suppl. 2: 34–9

    Article  PubMed  Google Scholar 

  14. Bono AV, Cuffari S. Efficacité et tolérance du tramadol dans les douleurs néoplasiques: étude comparative par rapport à la buprénorphine. Drugs 1997; 53 Suppl. 2: 40–49

    Article  PubMed  Google Scholar 

  15. Cossmann M, Kohnen C, Langford R, et al. Tolérance et sécurité d’emploi du tramadol: résultats des études internationales et données de la pharmacovigilance. Drugs 1997; 53 Suppl. 2: 50–62

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Besson, JM. The Place of Tramadol in the Therapy of Pain. Drugs 53 (Suppl 2), 65–66 (1997). https://doi.org/10.2165/00003495-199700532-00012

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00003495-199700532-00012

Keywords

Navigation