MGluR5 Mediates the Interaction between Late-LTP, Network Activity, and Learning
Figure 5
Induction phase of LTP is enhanced in CA3-lesioned animals after prolonged MPEP treatment.
A. A transverse section through the rat brain at the level of ca. 3.1–3.3 mm posterior to bregma, demonstrating the lesioning of the hippocampal CA3 region as a result of kainate injection. B. Daily administration of MPEP for three days in CA3-lesioned rats resulted in an enhanced induction of LTP in CA1 region in comparison with CA3-lesioned animals that were treated with vehicle. Data are represented as mean±S.E.M. C. Analogues represent (i) pre-HFT, (ii) 5 min post-HFT and (iii) 24h post-HFT, in CA3-lesioned animals following treatment either with vehicle or MPEP. Vertical bar: 2 mV, horizontal bar: 5 msec.