MGluR5 Mediates the Interaction between Late-LTP, Network Activity, and Learning
Figure 3
An impairment of LTP occurred after prolonged mGluR5 antagonism is partly mediated by mGluR1 in the dentate gyrus.
A, B. HFT induces robust LTP of PS amplitude (A) and fEPSP slope (B) in controls treated with vehicle for three days (open circles). Prolonged application of MPEP (filled circles) results in a significant impairment of LTP induced 30 min after the final injection, compared to vehicle-injected controls. Potentiation of mGluR1 by Ro67-4853 after treatment with MPEP (grey diamonds) led to a significant recovery of late-LTP. Data are represented as mean±S.E.M. C. Analogues represent fEPSP responses during pre-HFT baseline, 5 min post-HFT and 24h post-HFT period, recorded after treatment with (i) vehicle, (ii) MPEP, and (iii) MPEP and Ro67-4853. Scale bars: vertical 2 mV, horizontal 5 ms.