MGluR5 Mediates the Interaction between Late-LTP, Network Activity, and Learning
Figure 2
Prolonged mGluR5 antagonism results in reduced expression of mGluR1 in the dentate gyrus, but not in CA1 region.
Expression of mGluR5, mGluR2/3 and NR2A remain unchanged both in the dentate gyrus and CA1. A, B. Western blot analysis of NR2A, mGluR5, mGluR1 and mGluR2/3 receptors in the dentate gyrus (A) and in the CA1 region (B). Each lane shows receptor expression in individual animals from control and treated groups. C, D. Densitometric analysis of NR2A, mGluR5, mGluR1 and mGluR2/3 expression are shown in the dentate gyrus (C) and in CA1 (D), following acute or prolonged treatment with MPEP. Each individual value was normalized by the expression of ß-actin. Values are mean±S.E.M of six individual determinations. Asterix denotes statistically significant difference (p<0.05).