Abstract
The in vitro biocompatibility of newly developed wound dressings consisting of different chitosan salts (chitosan lactate, glutamate and chloride) and a chitosan derivative (methylpyroolidinone chitosan) was compared with three commercially available wound dressings made of collagen, calciumalginate, and gelatin, by evaluation in a fibroblast cell culture system. Three experimental models which reflect relevant stages of wound healing were used, and the significant influence of the experimental setting on the results was demonstrated. Collagen and methylpyrrolidinone chitosan were the most compatible materials under the investigated test conditions. Chitosan chloride and glutamate were the least compatible substances. The results indicated that wound dressings made of chitosan lactate and methylpyrrolidinone chitosan as well as the three commercially available dressings are well tolerated.
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H. L. WONG and S. M. WAHL, in “Peptide growth factors and their receptors”, edited by M. B. Sporn and A. B. Roberts (Springer, 1990) p. 510.
T. D. TURNER, in “Encyclopedia of pharmaceutical Technology”, Vol. 4, edited by J. Swarbrick and J. C. Boylan (Marcel Dekker, 1991) p. 283.
P. SANDFORD, in “Chitin and chitosan”, edited by G. Skjakbraek, T. Anthonsen and P. Sandford (Elsevier Applied Science, 1989) p. 51.
C. J. BRINE, ibid. p. 679
B. CHITHAMBARA THANOO, M. C. SUNNY and JAYAKRISHNAN, J. Pharm. Pharmacol. 44 (1991) 283.
K. INOUYE, Y. MACHIDA, T. SANNANI and T. NAGAI, Drug Dev. Deliv. 4 (1989) 55.
N. SUJATHA, C. R. SUDHAKARAN and A. PADMANABHAN, Indian J. Pharm. Sci, 53 (1991) 113.
Y. KAWASHIMA, S. Y. LIU, A. KASAI, T. HANDA and H. TAKENAKA, Chem. Pharm. Bull. 33 (1985) 2107.
Y. SAWAYANAGI, N. NAMBU and T. NAGAI, Chem. Pharm. Bull. 30 (1982) 4216.
S. M. UPADRASHTA, P. R. KATIKANENI and N. O. NUESSLE, Drug Dev. Ind. Pharm. 18 (1992) 1701.
G. BIAGINI, A. BERTANI, R. MUZZARELLI, A. DAMADEI, G. DIBENEDETTO, A. BELLIGOLLI, G. RICOTTI, C. ZUCCHINI and C. RIZZOLI, Biomaterials 12 (1991) 281.
R. MUZZARELLI, G. BIAGINI, A. DAMADEI, A. PUGNALONI and J. DALIO, in: “Industrial polysaccharides: biomedical and biotechnological advances”, edited by V. CRESCENTI, S. STIVALA and J. DEA (Gordon & Breach, New York, 1990) p. 77.
R. MUZZARELLI, M. WECKX and V. BIACHIEGA, Chimicaoggi 4 (1991) 33.
R. MUZZARELLI, T. RENATO, O. FILIPPINI, E. GIOVANETTI, G. BIAGINI and P. E. VARALDO, Antimicrobial Agents and Chemotherapy 34 (1990) 2019.
J. KNAPCZYK, A. B. MACURA and B. PAWLIK, Int. J. Pharm. 80 (1992) 33.
T. MOSMAN, J. Immunol. Meth. 65 (1983) 55.
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Berscht, P.C., Nies, B., Liebendörfer, A. et al. In vitro evaluation of biocompatibility of different wound dressing materials. J Mater Sci: Mater Med 6, 201–205 (1995). https://doi.org/10.1007/BF00146856
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DOI: https://doi.org/10.1007/BF00146856