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Urinary functional outcomes in female neobladder patients

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Abstract

Purpose

The ratio between orthotopic and non-orthotopic diversions in women is far lower than in male patients. Data on urinary function in female patients with neobladders are therefore sparse.

Methods

We investigated the urinary function of female neobladder patients utilizing the Bladder Cancer Index, a validated and reliable health-related quality-of-life (HRQOL) questionnaire. Furthermore, we tried to identify preoperative factors that may influence functional results. All living female patients with an orthotopic neobladder (N = 82) from the University of Southern California Bladder Cancer Database were sent a questionnaire including the University of Michigan Bladder Cancer Index. Univariate analyses were performed using the Kruskal–Wallis test followed by a multivariate stepwise regression model.

Results

Fifty-six patients (68.3 %) responded and were included in the analysis. Thirty-five (62.5 %) of these patients had to catheterize their neobladder to a certain amount, while 25 patients (44.6 %) depend on catheterization to empty their neobladder. Univariate analyses showed that patient age (>65 years) was the only variable associated with a statistically significant lower rate of neobladder catheterization. Better urinary bother scores were associated with organ-confined disease (p = 0.038) and education level (p = 0.01). However, these variables were not significant in a multivariate stepwise linear regression model.

Conclusion

Considerably more women require urinary catheterization to void than previously reported. In this study, representing the largest investigated cohort in this topic, we were unable to identify any predictors of this outcome or any other urinary HRQOL in this cohort.

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Conflict of interest

All authors of this manuscript declare that they have no conflict of interest.

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Authors and Affiliations

  1. Institute of Urology, USC/Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Ave, Los Angeles, CA, 90089, USA

    Georg Bartsch, Siamak Daneshmand, Sumeet Syan & Donald G. Skinner

  2. Department of Urology, Goethe University, Theodor Stern Kai 7, 60590, Frankfurt, Germany

    Georg Bartsch

  3. Department of Urology, Stanford University, 300 Pasteur Dr Suite S287, Palo Alto, Stanford, CA, 94305, USA

    Eila C. Skinner

  4. Department of Urologic Surgery, Center of Surgical Quality and Outcomes Research, Vanderbilt University, 2525 West End Ave Suite 600, Nashville, TN, 37203, USA

    David F. Penson

Authors
  1. Georg Bartsch
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  2. Siamak Daneshmand
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  3. Eila C. Skinner
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  4. Sumeet Syan
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  5. Donald G. Skinner
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  6. David F. Penson
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Correspondence to Georg Bartsch.

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Bartsch, G., Daneshmand, S., Skinner, E.C. et al. Urinary functional outcomes in female neobladder patients. World J Urol 32, 221–228 (2014). https://doi.org/10.1007/s00345-013-1219-8

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  • DOI: https://doi.org/10.1007/s00345-013-1219-8

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